L7NCR5 · L7NCR5_9SALA

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

139250100150200250300350
TypeIDPosition(s)Description
Site113Interaction with DNA
Binding site169Zn2+ (UniProtKB | ChEBI)
Binding site172Zn2+ (UniProtKB | ChEBI)
Binding site232Zn2+ (UniProtKB | ChEBI)
Binding site236Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processapoptotic process
Biological Processprotein tetramerization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Organism names

Accessions

  • Primary accession
    L7NCR5

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Binds DNA as a homotetramer.

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain10-27p53 transactivation
Domain93-282p53 DNA-binding
Region278-320Disordered
Compositional bias289-303Polar residues
Compositional bias304-320Basic and acidic residues
Domain316-355p53 tetramerisation
Region348-392Disordered

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    392
  • Mass (Da)
    44,087
  • Last updated
    2013-04-03 v1
  • Checksum
    E90297F5C5E32CAA
MVESEAAMDSLPLSQETFSQLWGSLPETLLPTTDDFFWQQDFDCTLGMDPHNQLQQEDVSSTLNNDLLRAYEVALPEALPLEPPAATSAVPSTEDYPGTYNFRLAFQQSGTAKSVTCTYSPDLNKLFCQLAKTCPVKMTVSTPPPPGAFVRATAVYKKSQHIAEVVKRCPHHERSGDPSDGTAPSNHLIRVEGNYKAEYKESGATRRHSVLVPYETPQVGSDCTTVLYNYMCNSSCMGGMNRRPILTIITLETNDGQLLGRCCFEVRVCACPGRDRKTEEENFHNKKKPSKNAVNTGTKRTIKDASLTETDVENPKRKAHEEDEIYTLQIRGRERYEMLKKLNDALELKDMIPQSDQEKIKQKFQKPRKERENPAPKNGKKLLVKDESQDSD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias289-303Polar residues
Compositional bias304-320Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM627863
EMBL· GenBank· DDBJ
AEI91929.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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