L0ER83 · L0ER83_ATRPE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    L0ER83

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-41Helical
Transmembrane61-88Helical
Transmembrane108-129Helical
Transmembrane149-173Helical
Transmembrane185-212Helical
Transmembrane232-257Helical
Transmembrane269-293Helical
Transmembrane305-328Helical
Transmembrane340-361Helical
Transmembrane381-404Helical
Transmembrane416-438Helical
Transmembrane458-478Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-517Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    519
  • Mass (Da)
    57,973
  • Last updated
    2013-03-06 v1
  • Checksum
    0F603EE1391F7CAC
MKQWNWIYRWVCSTNHKDIGTLYLLLGLWSGMVGTGFSVIIRTELCRPGATYLGDGQLYNSIVTAHAFIMIFFFVMPMMIGGFGNWLIPMMMGVPDMAFPRLNNLSFWLLPSSLYCLFLSAFVEGGAGTGWTVYPPLSTYLYHGMSVDLAIFSLHLAGLASIFGGINFIVTAQNMRRMESHLMDLFPWAVLVTAVLLVVSLPVLAGGITMLLTDRHFNTSFYFPGGGGDPVLFQHLFWFFGHPEVYILILPAFGMISHMVCHWSFKLEVFGGLAMIYAMVGIGVLGFIVWGHHMFTVGMDVNSRAYFSAATLIIAVPTGVKVFSWIATMSGCRVKSSAPVLWSVGFLGLFTFGGLTGVILASASVDIVLHDTYFVTGHFHYVLSMGAVFALFGAFNHWFPLFTGLTLHRRLAKSQFVGMFLGVNLTFFPHHFLGLSGMPRRIIDYPDCYAKWNSVSSWGSMLSFVGLMWFSFILWEAFMAQRPILFMNNVSVFLEWMGGPKYPPASHGWLFEAPSIWKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC153059
EMBL· GenBank· DDBJ
AGA63948.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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