L0E6E0 · L0E6E0_9CARA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • BARA_545
    • BARA_546
    • BARA_548
    • MFAR_153
    • MFAR_154
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Carabinae > Carabini > Carabina > Carabus > Mesocarabus

Accessions

  • Primary accession
    L0E6E0

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane24-50Helical
Transmembrane71-89Helical
Transmembrane119-142Helical
Transmembrane154-181Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-193Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    193
  • Mass (Da)
    20,712
  • Last updated
    2013-03-06 v1
  • MD5 Checksum
    4B1BDC589635CEA40C6C223C91FC5F34
GTSLSMLIRAELGNPGSLIGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLMSSMVEKGAGTGWTVYPPLSSGIAHSGASVDLAIFSLHLAGISSILGAVNFITTIINMRSVGMTFDRMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue193

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX278050
EMBL· GenBank· DDBJ
AGA54754.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278052
EMBL· GenBank· DDBJ
AGA54756.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278053
EMBL· GenBank· DDBJ
AGA54757.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278054
EMBL· GenBank· DDBJ
AGA54758.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278055
EMBL· GenBank· DDBJ
AGA54759.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278064
EMBL· GenBank· DDBJ
AGA54768.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278065
EMBL· GenBank· DDBJ
AGA54769.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278067
EMBL· GenBank· DDBJ
AGA54771.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278125
EMBL· GenBank· DDBJ
AGA54829.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278126
EMBL· GenBank· DDBJ
AGA54830.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278127
EMBL· GenBank· DDBJ
AGA54831.1
EMBL· GenBank· DDBJ
Genomic DNA
JX278176
EMBL· GenBank· DDBJ
AGA54880.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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