K9ZK79 · K9ZK79_ANACC

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site129(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site133-135(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site237Plays an important role in substrate specificity
Binding site362-364(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • Ordered locus names
      Anacy_3798

Organism names

Accessions

  • Primary accession
    K9ZK79

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue238N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-393Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    47,046
  • Last updated
    2013-03-06 v1
  • MD5 Checksum
    9570E7D5A09CE2CAB11DBEEA93CE102D
MFQRIVNVNKTSSDLLKSADPAISELINQELQRQRDHLELIASENFTSAAVLAAQGSVLTNKYAEGLPGKRYYGGCEFVDKIEQIAIDRAKQLFGAAHANVQPHSGAQANFAVFLTLLEPGDTIMGMDLSHGGHLTHGSPVNVSGKWFQVRHYGVSQETEQLDYDQIRELALKERPKLLICGYSAYPRIIDFEKFRSIADEVGAYLLADIAHIAGLVATGHHPNPLPYCDVVTTTTHKTLRGPRGGLILTRNAELGKKLDKSVFPGTQGGPLEHVIAGKAVAFGEALKPEFTTYSAQVIDNARALATQLQKRGFKLVSNGTDNHLMLVDLRSIGMTGKKGDQLVSGVNITANKNTVPFDPESPFVTSGLRLGSPAMTTRGLGVAEFTEIGDIISDRLLSPDSETVAADCLQRVAALCDRFPLYPHIEIPLPVLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003659
EMBL· GenBank· DDBJ
AFZ59179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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