K9MS24 · K9MS24_HUMAN
- ProteinSpectrin beta chain
- GeneSPTBN1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2364 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell junction | |
Cellular Component | cell projection | |
Cellular Component | plasma membrane | |
Cellular Component | spectrin | |
Molecular Function | actin filament binding | |
Molecular Function | phospholipid binding | |
Molecular Function | structural constituent of cytoskeleton | |
Biological Process | actin cytoskeleton organization | |
Biological Process | actin filament capping | |
Biological Process | protein localization to plasma membrane |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSpectrin beta chain
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionK9MS24
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 54-158 | Calponin-homology (CH) | ||||
Sequence: AVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGPHDIVDGNHRLTLGLIWTIILRFQ | ||||||
Domain | 173-278 | Calponin-homology (CH) | ||||
Sequence: KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKRSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFS | ||||||
Coiled coil | 457-491 | |||||
Sequence: VEAATKKHEAIETDIAAYEERVQAVVAVARELEAE | ||||||
Coiled coil | 991-1032 | |||||
Sequence: VMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQA | ||||||
Coiled coil | 1097-1124 | |||||
Sequence: AEKLLTQHENIKNEIDNYEEDYQKMRDM | ||||||
Coiled coil | 1422-1456 | |||||
Sequence: QQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEV | ||||||
Coiled coil | 1853-1880 | |||||
Sequence: IQALGTQVRQLQEDAARLQAAYAGDKAD | ||||||
Compositional bias | 2089-2105 | Basic and acidic residues | ||||
Sequence: RQQEEEERKRRPPSPEP | ||||||
Region | 2089-2196 | Disordered | ||||
Sequence: RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETP | ||||||
Compositional bias | 2108-2178 | Polar residues | ||||
Sequence: KVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKT | ||||||
Domain | 2197-2307 | PH | ||||
Sequence: SAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAIS | ||||||
Compositional bias | 2309-2340 | Polar residues | ||||
Sequence: DKHEVSASTQSTPASSRAQTLPTSVVTITSES | ||||||
Region | 2309-2364 | Disordered | ||||
Sequence: DKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSIFGKKK | ||||||
Compositional bias | 2341-2357 | Basic and acidic residues | ||||
Sequence: SPGKREKDKEKDKEKRF |
Sequence similarities
Belongs to the spectrin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,364
- Mass (Da)274,418
- Last updated2013-03-06 v1
- ChecksumBCD2A5EBAE0600F2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2089-2105 | Basic and acidic residues | ||||
Sequence: RQQEEEERKRRPPSPEP | ||||||
Compositional bias | 2108-2178 | Polar residues | ||||
Sequence: KVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKT | ||||||
Compositional bias | 2309-2340 | Polar residues | ||||
Sequence: DKHEVSASTQSTPASSRAQTLPTSVVTITSES | ||||||
Compositional bias | 2341-2357 | Basic and acidic residues | ||||
Sequence: SPGKREKDKEKDKEKRF |