K9IZ24 · K9IZ24_DESRO

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site228Proton donor
Binding site228-232AMP (UniProtKB | ChEBI)
Binding site232Zn2+ 1 (UniProtKB | ChEBI)
Binding site268Zn2+ 1 (UniProtKB | ChEBI)
Binding site269AMP (UniProtKB | ChEBI)
Binding site269Zn2+ 2 (UniProtKB | ChEBI)
Binding site269Zn2+ 1 (UniProtKB | ChEBI)
Binding site376AMP (UniProtKB | ChEBI)
Binding site376Zn2+ 1 (UniProtKB | ChEBI)
Binding site427AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentneuronal cell body
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Desmodontinae > Desmodus

Accessions

  • Primary accession
    K9IZ24

Subcellular Location

Family & Domains

Features

Showing features for coiled coil, domain, compositional bias, region.

Type
IDPosition(s)Description
Coiled coil34-64
Domain151-528PDEase
Compositional bias457-481Polar residues
Region457-498Disordered
Compositional bias521-555Basic and acidic residues
Region521-633Disordered
Compositional bias567-587Polar residues
Compositional bias588-633Basic and acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    633
  • Mass (Da)
    71,744
  • Last updated
    2013-02-06 v1
  • Checksum
    5D99783CC6F8644E
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPRFKTIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVVNWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWELHHRWTMLLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPFIDETSQAGGTGQRRSSLNSLSSADAKRSGVKSAGSEGSAPINNSVIPVDCKNFKVTWTEVVHVNRERWKAKVPKEEKAKKEAEEKARLAAEEKQKETEGKNQAEDGGAGGAEKTSGAAQSQVNGTRPNKGGNSRGKNSKVEKPSGEKQQNGDLKDGKNKADKKDQSNVGNDSKKTEDSEE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias457-481Polar residues
Compositional bias521-555Basic and acidic residues
Compositional bias567-587Polar residues
Compositional bias588-633Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GABZ01004969
EMBL· GenBank· DDBJ
JAA48556.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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