K9IZ24 · K9IZ24_DESRO
- ProteinPhosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids633 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 228 | Proton donor | |||
Binding site | 228-232 | AMP (UniProtKB | ChEBI) | |||
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 268 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 269 | AMP (UniProtKB | ChEBI) | |||
Binding site | 269 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 269 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 376 | AMP (UniProtKB | ChEBI) | |||
Binding site | 376 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 427 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Desmodontinae > Desmodus
Accessions
- Primary accessionK9IZ24
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for coiled coil, domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 34-64 | ||||
Domain | 151-528 | PDEase | |||
Compositional bias | 457-481 | Polar residues | |||
Region | 457-498 | Disordered | |||
Compositional bias | 521-555 | Basic and acidic residues | |||
Region | 521-633 | Disordered | |||
Compositional bias | 567-587 | Polar residues | |||
Compositional bias | 588-633 | Basic and acidic residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length633
- Mass (Da)71,744
- Last updated2013-02-06 v1
- Checksum5D99783CC6F8644E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 457-481 | Polar residues | |||
Compositional bias | 521-555 | Basic and acidic residues | |||
Compositional bias | 567-587 | Polar residues | |||
Compositional bias | 588-633 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GABZ01004969 EMBL· GenBank· DDBJ | JAA48556.1 EMBL· GenBank· DDBJ | mRNA |