K9IVT5 · K9IVT5_PIG

  • Protein
    Ubiquitin carboxyl-terminal hydrolase
  • Gene
    BAP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular ComponentPR-DUB complex
Molecular Functionchromatin DNA binding
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functionhistone H2A deubiquitinase activity
Biological Processcommon myeloid progenitor cell proliferation
Biological Processerythrocyte maturation
Biological Processgene expression
Biological Processhematopoietic stem cell homeostasis
Biological Processin utero embryonic development
Biological Processleukocyte proliferation
Biological Processmacrophage homeostasis
Biological Processmitotic cell cycle
Biological Processmonoubiquitinated protein deubiquitination
Biological Processmyeloid cell apoptotic process
Biological Processnegative regulation of DNA-templated transcription
Biological Processneuron cellular homeostasis
Biological Processneutrophil differentiation
Biological Processnucleate erythrocyte differentiation
Biological Processplatelet morphogenesis
Biological Processregulation of cell cycle
Biological Processregulation of cell growth
Biological Processregulation of cytokine production involved in inflammatory response
Biological Processregulation of inflammatory response
Biological Processthrombocyte differentiation
Biological Processtissue homeostasis
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase
  • EC number

Gene names

    • Name
      BAP1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Duroc
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    K9IVT5
  • Secondary accessions
    • F1SIW6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain5-214UCH
Compositional bias274-306Polar residues
Region274-348Disordered
Region371-438Disordered
Region464-524Disordered
Region575-606Disordered
Compositional bias576-597Polar residues
Domain643-688UCH37-like C-terminal
Region703-729Disordered
Compositional bias704-729Basic residues

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    729
  • Mass (Da)
    80,653
  • Last updated
    2019-12-11 v1
  • Checksum
    0C292DCBB141BB6D
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTILESLQQLIRVTQPELIQTHKSQESQLPEESKPVSSKSPLSVEANRASVASEGTHTDGVEEVAGSCPQALTHSPPSKPKLMVKPPGSSLNGVPPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPIRPPQQYSDDEDDYEDDEEDDMQNTNSAIRYKRKGPGKPGPLSGSGDGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTESGKGSSPSVRLSQSSHGSGSPEEKDMVEAMDGREKPGLVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias274-306Polar residues
Compositional bias576-597Polar residues
Compositional bias704-729Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQIR01019164
EMBL· GenBank· DDBJ
HCZ74639.1
EMBL· GenBank· DDBJ
Transcribed RNA
DQIR01158525
EMBL· GenBank· DDBJ
HDB14002.1
EMBL· GenBank· DDBJ
Transcribed RNA
GACC01000077
EMBL· GenBank· DDBJ
JAA53730.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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