K8Y636 · K8Y636_9LEPT
- Protein1-deoxy-D-xylulose-5-phosphate synthase
- Genedxs
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids635 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Catalytic activity
- D-glyceraldehyde 3-phosphate + pyruvate + H+ = 1-deoxy-D-xylulose 5-phosphate + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit.
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway
Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 77 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 118-120 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 150 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 151-152 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 179 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 179 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 290 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 372 | thiamine diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 1-deoxy-D-xylulose-5-phosphate synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | 1-deoxy-D-xylulose 5-phosphate biosynthetic process | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process | |
Biological Process | thiamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-deoxy-D-xylulose-5-phosphate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionK8Y636
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Sequence
- Sequence statusComplete
- Length635
- Mass (Da)70,982
- Last updated2013-02-06 v1
- Checksum1D1842B88CDEDB48
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP006694 EMBL· GenBank· DDBJ | EKT86102.1 EMBL· GenBank· DDBJ | Genomic DNA |