K8Y140 · K8Y140_9LEPT

Function

function

Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site115[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site116[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site198[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site201[4Fe-4S] cluster (UniProtKB | ChEBI)
Active site225Nucleophile; cysteine thiosulfonate intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionphosphoadenylyl-sulfate reductase (thioredoxin) activity
Biological Processsulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine 5'-phosphosulfate reductase
  • EC number
  • Short names
    APS reductase
  • Alternative names
    • 5'-adenylylsulfate reductase
    • Thioredoxin-dependent 5'-adenylylsulfate reductase

Gene names

    • Name
      cysH
    • ORF names
      LSS_08254

Organism names

Accessions

  • Primary accession
    K8Y140

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-204Phosphoadenosine phosphosulphate reductase

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    28,084
  • Last updated
    2013-02-06 v1
  • Checksum
    45BB381F7CD51997
MLPQELEQKLALLSLEDSLEWISNEYGETAAFSTSLGLEDQVITHVIYTRNLKIRIFTLDTGRLFNETYDLHKLTNASYGRKIETYFPDTASVQNLINTKGPDSFYDSVENRKECCYIRKVEPLNRALVGTKLWITGIRSEQSDSRNSLTKVELDSSRNILKYHPLLDWSLERTQDFIDTYRIPTNVLHKKGFPSIGCAPCTRAVQPGEDIRAGRWWWEASNQECGLHVVDGKLVRQKSGPKRAI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006694
EMBL· GenBank· DDBJ
EKT87353.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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