K8XVS2 · K8XVS2_9LEPT

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

118220406080100120140160180
TypeIDPosition(s)Description
Active site140
Active site162

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      LSS_17380

Organism names

Accessions

  • Primary accession
    K8XVS2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-36Helical
Transmembrane43-64Helical
Transmembrane70-87Helical
Transmembrane99-117Helical
Transmembrane155-176Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    20,921
  • Last updated
    2013-02-06 v1
  • Checksum
    CE9EF1627DD464BE
MKYFEKRFLDVYRPLYIGVVLFGIVLDLATKFLVILYFEPHRYLEVLGSFFRMTLTFNTGFVFGAFQDNAIPSLIATGIAIVFLIGYRWKNYDLGNPWGWNLVMAGAFGNFLDKFFVKIPGTGFRFGFQPNAGEYIGVVDFLDFDWPDFLLFSRWPAFNVADSCVTIGLTILIFTMKLEEGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006694
EMBL· GenBank· DDBJ
EKT85464.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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