K7W909 · K7W909_OCHER
- ProteinMyoglobin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids154 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.
Catalytic activity
- AH2 + H2O2 = A + 2 H2O
- Fe(III)-heme b-[protein] + nitric oxide + H2O = Fe(II)-heme b-[protein] + nitrite + 2 H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | sarcoplasm | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | oxygen binding | |
Molecular Function | oxygen carrier activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyoglobin
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona
Accessions
- Primary accessionK7W909
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length154
- Mass (Da)17,082
- Last updated2013-02-06 v1
- Checksum2A6526853F801D77
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JX827175 EMBL· GenBank· DDBJ | AFX00022.1 EMBL· GenBank· DDBJ | mRNA |