K7GHE4 · K7GHE4_PELSI

Function

Catalytic activity

  • (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA
    This reaction proceeds in the forward direction.
  • (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3E)-decenoyl-CoA = (2E)-decenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + NADH + H+
    This reaction proceeds in the forward direction.
  • (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + NADH + H+
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + NADH + H+
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.35 (UniProtKB | ENZYME | Rhea)
  • a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.17 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; fatty acid beta-oxidation.

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal bifunctional enzyme
  • EC number
  • Alternative names
    • Multifunctional enzyme 1

Gene names

    • Name
      EHHADH

Organism names

Accessions

  • Primary accession
    K7GHE4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain203-3823-hydroxyacyl-CoA dehydrogenase NAD binding
Domain385-4893-hydroxyacyl-CoA dehydrogenase C-terminal
Domain526-6133-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    69,208
  • Last updated
    2013-01-09 v1
  • Checksum
    29C0F3E1C5D77AA8
MALGGGLEVALGCHYRIAQAQAWVGLPEVTLGILPAAGGTQRLPRLIGVPAALDIITTGRRVLAAEALKLGIIDEIVEGNTIEAAIHLANKVSGQPLNPRRLSLKQVQSLPNMDTIFREALEKVKKQARGFLSPELCVQAVKASVQLPFTEGIWKEREFLHYLVTSGQAKAMQYAFFAQRAVQKWTTPSGASWKTASAQPIRKVAVIGLGTMGRGIVISLVKAKMSVVTLEQDQKHLEIGRRAVTSLLEHEASKMQRSGQSPDACDPAHVQFTVDFGVLQDVDLVIEAVFEDMALKKEIFRKVSAVCKPEAFLCTNTSALDIDEIAAVTSRPQQVVGTHFFSPAHVMKLLEIIHGRHTSPTTIATAMGLAKTIGKIGVVVGNCFGFVGNRMMAPYIEQAVFLLEEGCKPEEVDQALEGFGFNMGPFRLSDLAGLDVGWRSRKGQGLTGPGLAPGTPARLRDRRRYSPLPDLLCENGRYGQKTGMGWYQYEKPGARIANPDPWLHNFLRDYRDAHHIQARFIDQEEILERCLYALINEGFRILDDGIACAPEDIDVIYSHGYGWPKHRGGPMFYASDIGLPHILAKLQKYSEAHPDIPRVQPSAFLKKLVSIGSPPLKEWMSHAGHRSSKL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
K7GHF1K7GHF1_PELSIEHHADH708

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCU01091537
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01091538
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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