K7GHE4 · K7GHE4_PELSI
- ProteinPeroxisomal bifunctional enzyme
- GeneEHHADH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids630 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoAThis reaction proceeds in the forward direction.
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3E)-decenoyl-CoA = (2E)-decenoyl-CoAThis reaction proceeds in the forward direction.
- (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
- (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoAThis reaction proceeds in the backward direction.
- (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoAThis reaction proceeds in the backward direction.
- (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + NADH + H+This reaction proceeds in the forward direction.
- (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + NADH + H+This reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + NADH + H+This reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal bifunctional enzyme
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Trionychia > Trionychidae > Pelodiscus
Accessions
- Primary accessionK7GHE4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 203-382 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: KVAVIGLGTMGRGIVISLVKAKMSVVTLEQDQKHLEIGRRAVTSLLEHEASKMQRSGQSPDACDPAHVQFTVDFGVLQDVDLVIEAVFEDMALKKEIFRKVSAVCKPEAFLCTNTSALDIDEIAAVTSRPQQVVGTHFFSPAHVMKLLEIIHGRHTSPTTIATAMGLAKTIGKIGVVVGN | ||||||
Domain | 385-489 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFVGNRMMAPYIEQAVFLLEEGCKPEEVDQALEGFGFNMGPFRLSDLAGLDVGWRSRKGQGLTGPGLAPGTPARLRDRRRYSPLPDLLCENGRYGQKTGMGWYQY | ||||||
Domain | 526-613 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: ILERCLYALINEGFRILDDGIACAPEDIDVIYSHGYGWPKHRGGPMFYASDIGLPHILAKLQKYSEAHPDIPRVQPSAFLKKLVSIGS |
Sequence similarities
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length630
- Mass (Da)69,208
- Last updated2013-01-09 v1
- Checksum29C0F3E1C5D77AA8
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
K7GHF1 | K7GHF1_PELSI | EHHADH | 708 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGCU01091537 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01091538 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |