K7GET2 · SCNNA_PELSI

Function

function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentapical plasma membrane
Cellular Componentciliary membrane
Cellular Componentcytoplasm
Cellular Componentextracellular exosome
Cellular Componentmotile cilium
Cellular Componentsodium channel complex
Molecular Functionligand-gated sodium channel activity
Molecular FunctionWW domain binding
Biological Processcellular response to acidic pH
Biological Processintracellular sodium ion homeostasis
Biological Processmulticellular organismal-level water homeostasis
Biological Processsodium ion import across plasma membrane
Biological Processsodium ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Amiloride-sensitive sodium channel subunit alpha
  • Alternative names
    • Alpha-NaCH
    • Epithelial Na(+) channel subunit alpha (Alpha-ENaC)
    • Nonvoltage-gated sodium channel 1 subunit alpha
    • SCNEA

Gene names

    • Name
      SCNN1A

Organism names

Accessions

  • Primary accession
    K7GET2

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-81Cytoplasmic
Transmembrane82-102Helical; Name=1
Topological domain103-553Extracellular
Transmembrane554-574Helical; Name=2
Topological domain575-642Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004329101-642Amiloride-sensitive sodium channel subunit alpha

Interaction

Subunit

Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region170-209Disordered
Compositional bias182-197Basic residues
Region587-608Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    642
  • Mass (Da)
    73,892
  • Last updated
    2013-01-09 v1
  • Checksum
    C32BF6DF0CA49C21
MHQVVTVKAEKVPMGKRLRRCKQEAENQQKVEEVAEKLEKEHEGLIEFHKSYHELFQFFCNNTTIHGAIRLVCSKRNKMKTAFWSVLFFLTFGLMYWQFGILYREYFSFPVNLNLNLNSDKLTFPAVTLCTLNPYRYSAVRKELDELDRITHQTLMDLYNYSMSQVQSNGAAQSSQKRSQRSLSHHVQRHPLRRRKRNEPVSLKGNSPPVDKSDWKIGFILCNETNEDCFHQTYSSGVDAVREWYSFHYINILARMPDTKALDESNFESFIYACRFNEVTCDKANYTHFHHPLYGNCYTFNDRNNSLWTSSLPGINNGLSLLVRTEQNDYIPLLSTVTGARVMVHEQNEPAFMDDGGFNVRPGIETSISMRKETTMLLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQIHMVKRCGCAYYFYPLPPGAEYCDYTKHIAWGYCYYKLQVEFKSNILGCFSKCRKPCEVTKYQLSAGYSHWPSAVSENWVFHILSQQNKYNITSKRNGVAKVNIFFEEWKYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVVELAELILDFIAITIILSFKRFRSRQVPAPSVPPPGAHDNTAFQSEPADPSAPHRFTVEAVVTTLPSYNSLEPCRRDGEAVIGLE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias182-197Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCU01093992
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01093993
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01093994
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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