K7GDN4 · K7GDN4_PELSI

Function

function

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.

Catalytic activity

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site65NAD+ (UniProtKB | ChEBI)
Binding site110NAD+ (UniProtKB | ChEBI)
Binding site152NAD+ (UniProtKB | ChEBI)
Binding site181-183D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site182Nucleophile
Site209Activates thiol group during catalysis
Binding site212D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site241-242D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site264D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site346NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoskeleton
Cellular Componentcytosol
Cellular ComponentGAIT complex
Cellular Componentlipid droplet
Cellular Componentnuclear membrane
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Molecular Functionaspartic-type endopeptidase inhibitor activity
Molecular Functiondisordered domain specific binding
Molecular Functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Molecular Functionidentical protein binding
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionpeptidyl-cysteine S-nitrosylase activity
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processapoptotic process
Biological Processcellular response to type II interferon
Biological Processdefense response to fungus
Biological Processglucose metabolic process
Biological Processglycolytic process
Biological Processkilling by host of symbiont cells
Biological Processnegative regulation of endopeptidase activity
Biological Processnegative regulation of translation
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of type I interferon production

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      GAPDH

Organism names

Accessions

  • Primary accession
    K7GDN4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-182Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    39,519
  • Last updated
    2013-01-09 v1
  • Checksum
    1E43FAA0E8887C18
RLFSALPRFGRIGRLVTRAAFTCDKVQIVAINDPFIDLNYMVSGTLVYNLEHSGCDKVQIVAINDPFIDLNYMVYMFKYDSTHGRFHGTVKAENGKLVINGQAITIFQERDPANIKWGDAGAEYVVESTGVFTTTEKASAHLKGGAKRVVISAPSADAPMFVMGVNHEKYDNSLKVVSNASCTTNCLAPLAKVIHDNYGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLQKPAKYDDIKKVMKAASEGPLKGILGYTEDQVVSSDFNGDSRSSIFDAAAGIALNDNFVKLVSWYDNEFGYSNRVVDLLVHMASKE

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
K7GDM5K7GDM5_PELSIGAPDH293

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCU01093985
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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