K7G3M1 · K7G3M1_PELSI
- ProteinCadherin EGF LAG seven-pass G-type receptor 1
- GeneCELSR1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2740 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Receptor that may have an important role in cell/cell signaling during nervous system formation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Trionychia > Trionychidae > Pelodiscus
Accessions
- Primary accessionK7G3M1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2182-2205 | Helical | ||||
Sequence: IVTYTTVSISLVALLMTFMLLVLI | ||||||
Transmembrane | 2217-2235 | Helical | ||||
Sequence: RNLVAALFFSELVFLIGIN | ||||||
Transmembrane | 2241-2263 | Helical | ||||
Sequence: FVCTVIAILLHYFYMSTFAWMFV | ||||||
Transmembrane | 2284-2304 | Helical | ||||
Sequence: RFYYVVGWGIPAIITGLAVGL | ||||||
Transmembrane | 2324-2345 | Helical | ||||
Sequence: IWSFAGPVVIVVIINTVIFILA | ||||||
Transmembrane | 2365-2387 | Helical | ||||
Sequence: VLRTAFLLLLLISATWLLGLMAV | ||||||
Transmembrane | 2393-2416 | Helical | ||||
Sequence: TFHYLFAIFSCLQGLFIFFFHCIF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 1064↔1073 | |||||
Sequence: CPPGFTGDYC | ||||||
Disulfide bond | 1102↔1111 | |||||
Sequence: CYEDYTGESC | ||||||
Disulfide bond | 1388↔1397 | |||||
Sequence: CPLQYGGKNC | ||||||
Disulfide bond | 1611↔1620 | |||||
Sequence: CDPGYFGSNC | ||||||
Disulfide bond | 1649↔1658 | |||||
Sequence: CGQSYYGQYC | ||||||
Disulfide bond | 1716↔1728 | |||||
Sequence: CDCFPSGSQTRSC | ||||||
Disulfide bond | 1718↔1735 | |||||
Sequence: CFPSGSQTRSCDLETGQC | ||||||
Disulfide bond | 1737↔1746 | |||||
Sequence: CKPGVIGRQC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-71 | Cadherin | ||||
Sequence: SNDYFSIDSETGSMVTTRSLDRETKDTHVLKVTATDHGSPRRRSATTYLTVTVSDTNDHEPMF | ||||||
Domain | 72-179 | Cadherin | ||||
Sequence: EQPVYRETIRENLEVGYEVLTIRATDGDAPDNANMLYRLLEPGAGDGVFEIDPRSGVVRTRAPVDREEVSEYHLVVEANDQGKEPGPRSATATVHITVEDENDNYPQF | ||||||
Domain | 180-285 | Cadherin | ||||
Sequence: SEKRYLVQVPEDAPVNSQVLQVQATDRDRGSNAQVHYSIVSGNLKGQFYIHSFSGAIDLINPLDYETIREYTLRIKAQDGGRPPLINSSGMVSVQVVDVNDNAPIF | ||||||
Domain | 286-401 | Cadherin | ||||
Sequence: VSTPFQATVLENVPLGYSVLHVQAVDADSGDNARLEYKLIDLSPSPGGVSPGGDTGFPFQINNSTGWITVSAELDRETVENYHFGVEARDHGVPVMTSSASVAITVLDVNDNNPSF | ||||||
Domain | 402-503 | Cadherin | ||||
Sequence: TEKVYQLRLNEDAAVGSSVLTVIAVDRDINSVVTYQITSGNTRNRFAITSQSGGGLITLALPLDYKQERQYVLTVTASDGTLLDTVQVFINVTDANTHRPVF | ||||||
Domain | 504-606 | Cadherin | ||||
Sequence: QSSHYTVSVSEDKPIGTSIVTISASDEDTGENARITYILEDNIPQFRIDPDTGTITTLMELDYEDQASYTLAITARDNGIPQKSDTTYVEILILDANDNAPRF | ||||||
Domain | 607-712 | Cadherin | ||||
Sequence: LRDRYQGSVFEDVPLSTSVLQLSATDRDSGLNGRLLYTFQGGDDGDGDFYIEPTSGVIRTLRKLDRENVAVYSLRAFAVDRGSPPLKASVDIQVTVLDINDNPPVF | ||||||
Domain | 713-814 | Cadherin | ||||
Sequence: EQDEFDIFVEENSPVGSIVARISAADPDEGTNAQIMYQIVEGNIPEVFQLDLLNGDLTALMDLDYESRTEYVIVVQATSAPLVSRATVHIRLLDQNDNPPVL | ||||||
Domain | 837-937 | Cadherin | ||||
Sequence: IGKIPAHDPDVSDSLAYAFVQGNELNLLLLDSATGELKLSRDLDNNRPLEALMKVSVSDGVHSVTAVCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLL | ||||||
Domain | 1016-1074 | EGF-like | ||||
Sequence: DDNICLREPCENYMKCVSVLKFDSSAPFISSNTVLFRPIHPINGLRCRCPPGFTGDYCE | ||||||
Domain | 1076-1112 | EGF-like | ||||
Sequence: EIDLCYSNPCGNNGLCRSREGGYTCECYEDYTGESCE | ||||||
Domain | 1116-1154 | EGF-like | ||||
Sequence: RSGRCVPGVCKNGGTCVNLLVGGFKCECPPGEYERPYCE | ||||||
Domain | 1155-1359 | Laminin G | ||||
Sequence: MTTRSFPPQSFVTFKGLRQRFHFTVSLMFATRERNALLLYNGRFNEKHDFIALEIIEEQIQLTFSAGETTTTVAPFVPGGVSDGQWHSVQVQYYNKPHIGRLGIPHGPSGEKVAVVTVDDCDTAVAVRFGSLIGNYTCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNREFIGCMRNLSIDNKPIDMASFIANNGTLAGC | ||||||
Domain | 1362-1398 | EGF-like | ||||
Sequence: QKNYCDTNWCQNGGTCVNKWNTYTCECPLQYGGKNCE | ||||||
Domain | 1402-1583 | Laminin G | ||||
Sequence: PSPQRFSGESIIVWSDLDITISVPWYIGLMFRTRKVNGMLMQANAGASSKINIQILNNYVQFEVYNGLNQVASLKMTQTRVSDGEWHHLLIELKSAKDGKDIKYLAVMSLDYGMYQSTVQIGNQLPGLKMKSIIVGGISGDQVSVQQGFYGCMQGVRMGETSTNVATLNMKQAIKINIKEGC | ||||||
Domain | 1585-1621 | EGF-like | ||||
Sequence: IDNPCDSSPCPQHSYCTDDWDSYSCVCDPGYFGSNCV | ||||||
Domain | 1622-1659 | EGF-like | ||||
Sequence: DVCNLNPCEHVSTCVHKPSSSHGYTCECGQSYYGQYCE | ||||||
Domain | 1716-1763 | Laminin EGF-like | ||||
Sequence: CDCFPSGSQTRSCDLETGQCPCKPGVIGRQCNRCDNPFAEVTIQGCEV | ||||||
Domain | 1748-1821 | G-protein coupled receptors family 2 profile 1 | ||||
Sequence: RCDNPFAEVTIQGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCNSERGWLPPELFNCTTLI | ||||||
Domain | 2180-2417 | G-protein coupled receptors family 2 profile 2 | ||||
Sequence: LKIVTYTTVSISLVALLMTFMLLVLIRTLRSNLHSIHRNLVAALFFSELVFLIGINQTENQFVCTVIAILLHYFYMSTFAWMFVEQLHIYRMLTEVRNINFGHMRFYYVVGWGIPAIITGLAVGLDPHGYGNPDFCWLSVHDTLIWSFAGPVVIVVIINTVIFILAVKASCGRRQRSFEKTGVMSVLRTAFLLLLLISATWLLGLMAVNSDVMTFHYLFAIFSCLQGLFIFFFHCIFN | ||||||
Compositional bias | 2482-2510 | Polar residues | ||||
Sequence: AAQKLSGSSSQARTGQTEADSSIFHRNPS | ||||||
Region | 2482-2547 | Disordered | ||||
Sequence: AAQKLSGSSSQARTGQTEADSSIFHRNPSKSNENDSDSDSELSLDEHSSSYASSHSSESEEDGIEM | ||||||
Compositional bias | 2511-2525 | Basic and acidic residues | ||||
Sequence: KSNENDSDSDSELSL | ||||||
Region | 2584-2665 | Disordered | ||||
Sequence: ECVTTSDGEDPGGKQKLKVETKVSVELHRENQVNHSNEAPQDNENEGQQKENKPVQQQNNQLPEQRKGILKNKVTYPPPLLD | ||||||
Compositional bias | 2594-2618 | Basic and acidic residues | ||||
Sequence: PGGKQKLKVETKVSVELHRENQVNH | ||||||
Compositional bias | 2633-2649 | Polar residues | ||||
Sequence: KENKPVQQQNNQLPEQR |
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length2,740
- Mass (Da)304,261
- Last updated2013-01-09 v1
- ChecksumF67CF48312F13C80
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2482-2510 | Polar residues | ||||
Sequence: AAQKLSGSSSQARTGQTEADSSIFHRNPS | ||||||
Compositional bias | 2511-2525 | Basic and acidic residues | ||||
Sequence: KSNENDSDSDSELSL | ||||||
Compositional bias | 2594-2618 | Basic and acidic residues | ||||
Sequence: PGGKQKLKVETKVSVELHRENQVNH | ||||||
Compositional bias | 2633-2649 | Polar residues | ||||
Sequence: KENKPVQQQNNQLPEQR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGCU01067599 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067600 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067601 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067602 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067603 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067604 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067605 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067606 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067607 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AGCU01067608 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |