K7FYD9 · K7FYD9_PELSI

Function

Catalytic activity

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site448substrate
Active site482Phosphocysteine intermediate
Binding site529substrate

GO annotations

AspectTerm
Cellular Componentalpha-beta T cell receptor complex
Cellular Componentcell-cell junction
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular Functioncell adhesion molecule binding
Molecular Functionnon-membrane spanning protein tyrosine phosphatase activity
Molecular Functionphosphorylation-dependent protein binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionprotein kinase binding
Molecular FunctionSH2 domain binding
Molecular FunctionSH3 domain binding
Molecular Functiontransmembrane receptor protein tyrosine phosphatase activity
Biological ProcessB cell receptor signaling pathway
Biological ProcessCD27 signaling pathway
Biological Processepididymis development
Biological Processhematopoietic progenitor cell differentiation
Biological ProcessMAPK cascade
Biological Processmegakaryocyte development
Biological Processmitotic cell cycle
Biological Processnatural killer cell mediated cytotoxicity
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of B cell receptor signaling pathway
Biological Processnegative regulation of humoral immune response mediated by circulating immunoglobulin
Biological Processnegative regulation of inflammatory response to wounding
Biological Processnegative regulation of innate immune response
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of MAPK cascade
Biological Processnegative regulation of mast cell activation involved in immune response
Biological Processnegative regulation of peptidyl-tyrosine phosphorylation
Biological Processnegative regulation of T cell proliferation
Biological Processnegative regulation of T cell receptor signaling pathway
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpeptidyl-tyrosine dephosphorylation
Biological Processpeptidyl-tyrosine phosphorylation
Biological Processplatelet aggregation
Biological Processplatelet formation
Biological Processpositive regulation of cell adhesion mediated by integrin
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processregulation of B cell differentiation
Biological Processregulation of ERK1 and ERK2 cascade
Biological Processregulation of G1/S transition of mitotic cell cycle
Biological Processregulation of release of sequestered calcium ion into cytosol
Biological ProcessT cell proliferation
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type
  • EC number

Gene names

    • Name
      PTPN6

Organism names

Accessions

  • Primary accession
    K7FYD9

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain24-120SH2
Domain130-242SH2
Domain273-544Tyrosine-protein phosphatase
Domain459-535Tyrosine specific protein phosphatases
Region568-629Disordered
Compositional bias586-623Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    629
  • Mass (Da)
    70,980
  • Last updated
    2013-01-09 v1
  • Checksum
    11C269B681E1CA8A
MPSCGSFGCSYPGPGCSPSRMVRWFHRDLSGLEAESLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNTGDYYDLYGGEKFATLSELVEYYTQQQGSLQDKDGTVIDLRYPLNCSDPTAERWYHGHLSGPAAESLLQSKAVPWTFLVRESLSKPGDFVLSVLTDQPKAEVPPTGAAGASGARLKVTHVKIMCENGRYTVGGAERFDSLADLVEHFKKTGIEEVSGSYVYLRQPYYATRVNAADIESRVHELNKQSPAEEMSKAGFWEEFDSLQKQEAKHLYDRHEGQRPENKGKNRYKNILPFDHSRVILQGRDPNILGADYINANYIKNKLISPDEVTKTYIASQGCLDATVNDFWQMVWQENSHIIVMTTREVEKGRNKCVPYWPEVGSSREYGPYVVENTQERDALEYKLRQLCISPVDDCEAVREIWQYQYLSWPDHGVPSEPGGVLSFLDQINQQQESIPEAGPIVVHCSAGIGRTGTIIVIDMIVDTISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYMAICQFIETTKKKLDVMQAQKGQAKESEYGNIAYPPALKNKHAKASRKSSKQKEEPTLYENLENLKGKKEERVRKQRSSEKEKLKGSLKKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias586-623Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCU01093907
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01093908
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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