K7DYH7 · K7DYH7_DANRE
- ProteinAdenosylhomocysteinase
- Geneahcyl2a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids497 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 122 | substrate | ||||
Sequence: T | ||||||
Binding site | 196 | substrate | ||||
Sequence: D | ||||||
Binding site | 221 | substrate | ||||
Sequence: E | ||||||
Binding site | 251 | substrate | ||||
Sequence: K | ||||||
Binding site | 255 | substrate | ||||
Sequence: D | ||||||
Binding site | 287-292 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GEVGKG | ||||||
Binding site | 308 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 411 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | hydrolase activity | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionK7DYH7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-67 | Disordered | ||||
Sequence: MRKVYSLQIEYPEQTREFDNRLTKTGRRSLSHSLSHSSTDSNSSGGSDAEDPENEVSPRDKQRMNSK | ||||||
Compositional bias | 27-50 | Polar residues | ||||
Sequence: RRSLSHSLSHSSTDSNSSGGSDAE | ||||||
Compositional bias | 52-67 | Basic and acidic residues | ||||
Sequence: PENEVSPRDKQRMNSK | ||||||
Domain | 256-417 | S-adenosyl-L-homocysteine hydrolase NAD binding | ||||
Sequence: NLYCCRESILDSLKKTADIMFGGKQVVVCGYGEVGKGCSAALKAMGSIVYVTEIDPICALQACMDGFRLTKLSDVVRQVDMVITCTGNKNVVVREHMDVMKNGCVVCNMGRSNTEINVSALKTPDLTWQHVRAQVDHIIWPDGKRMILLAEGRVLNLSSSTV |
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length497
- Mass (Da)55,560
- Last updated2013-01-09 v1
- ChecksumFB64777058B4F80D
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2BIG2 | A0A8M2BIG2_DANRE | ahcyl2a | 516 | ||
A0A8M9PMV0 | A0A8M9PMV0_DANRE | ahcyl2a | 515 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-50 | Polar residues | ||||
Sequence: RRSLSHSLSHSSTDSNSSGGSDAE | ||||||
Compositional bias | 52-67 | Basic and acidic residues | ||||
Sequence: PENEVSPRDKQRMNSK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR450696 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |