K7DQ27 · K7DQ27_PANTR
- ProteinFucosyltransferase
- GeneFUT9
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids359 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H+This reaction proceeds in the forward direction.
- a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III3-alpha-Fuc-nLc4Cer + GDP + H+This reaction proceeds in the forward direction.
- alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV3-alpha-Gal,III3-alpha-Fuc-nLc4Cer + GDP + H+This reaction proceeds in the forward direction.
- alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H+This reaction proceeds in the forward direction.
- an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+This reaction proceeds in the forward direction.
- an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+This reaction proceeds in the forward direction.
- an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+This reaction proceeds in the forward direction.
- beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H+This reaction proceeds in the forward direction.
Pathway
Glycolipid biosynthesis.
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi cisterna membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | trans-Golgi network membrane | |
Molecular Function | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | glycosphingolipid biosynthetic process | |
Biological Process | Lewis x epitope biosynthetic process | |
Biological Process | N-glycan fucosylation | |
Biological Process | neuron differentiation | |
Biological Process | neuronal stem cell division | |
Biological Process | oligosaccharide biosynthetic process | |
Biological Process | polysaccharide biosynthetic process | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | protein N-linked glycosylation | |
Biological Process | protein O-linked glycosylation | |
Biological Process | regulation of leukocyte tethering or rolling |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFucosyltransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionK7DQ27
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein
Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-30 | Helical | ||||
Sequence: FLIVCIILGCFMACLLIYI |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 62-169 | Fucosyltransferase N-terminal | ||||
Sequence: NETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYG |
Sequence similarities
Belongs to the glycosyltransferase 10 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length359
- Mass (Da)42,071
- Last updated2013-01-09 v1
- ChecksumD57CFCB039B644D9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GABE01006277 EMBL· GenBank· DDBJ | JAA38462.1 EMBL· GenBank· DDBJ | mRNA |