K7DQ27 · K7DQ27_PANTR

Function

Catalytic activity

  • a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H+
    This reaction proceeds in the forward direction.
    EC:2.4.1.152 (UniProtKB | ENZYME | Rhea)
  • a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III3-alpha-Fuc-nLc4Cer + GDP + H+
    This reaction proceeds in the forward direction.
  • alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV3-alpha-Gal,III3-alpha-Fuc-nLc4Cer + GDP + H+
    This reaction proceeds in the forward direction.
  • alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H+
    This reaction proceeds in the forward direction.
  • an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+
    This reaction proceeds in the forward direction.
  • an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+
    This reaction proceeds in the forward direction.
  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H+
    This reaction proceeds in the forward direction.
  • beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H+
    This reaction proceeds in the forward direction.

Pathway

Glycolipid biosynthesis.
Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular ComponentGolgi cisterna membrane
Cellular ComponentGolgi membrane
Cellular Componenttrans-Golgi network membrane
Molecular Function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
Molecular Functionprotein homodimerization activity
Biological Processglycosphingolipid biosynthetic process
Biological ProcessLewis x epitope biosynthetic process
Biological ProcessN-glycan fucosylation
Biological Processneuron differentiation
Biological Processneuronal stem cell division
Biological Processoligosaccharide biosynthetic process
Biological Processpolysaccharide biosynthetic process
Biological Processpositive regulation of neuron projection development
Biological Processprotein N-linked glycosylation
Biological Processprotein O-linked glycosylation
Biological Processregulation of leukocyte tethering or rolling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fucosyltransferase
  • EC number

Gene names

    • Name
      FUT9

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    K7DQ27
  • Secondary accessions
    • A0A2J8PV31

Subcellular Location

Golgi apparatus membrane
Golgi apparatus, Golgi stack membrane
; Single-pass type II membrane protein
Golgi apparatus, trans-Golgi network membrane
; Single-pass type II membrane protein
Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-30Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain62-169Fucosyltransferase N-terminal

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    42,071
  • Last updated
    2013-01-09 v1
  • Checksum
    D57CFCB039B644D9
MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWIFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GABE01006277
EMBL· GenBank· DDBJ
JAA38462.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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