K7D3Y2 · K7D3Y2_PANTR
- ProteinLactosylceramide 4-alpha-galactosyltransferase
- GeneA4GALT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H+This reaction proceeds in the forward direction.
- a beta-D-Gal-(1<->1')-ceramide + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + UDP + H+This reaction proceeds in the forward direction.
Pathway
Glycolipid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Molecular Function | acetylglucosaminyltransferase activity | |
Molecular Function | galactosyltransferase activity | |
Molecular Function | lactosylceramide 4-alpha-galactosyltransferase activity | |
Molecular Function | toxic substance binding | |
Biological Process | globoside biosynthetic process | |
Biological Process | plasma membrane organization | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactosylceramide 4-alpha-galactosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionK7D3Y2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-42 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,515
- Last updated2013-01-09 v1
- MD5 Checksum67BD9BEDDEC5C520554ABE1F5EDF901F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACZ04043580 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
GABC01007261 EMBL· GenBank· DDBJ | JAA04077.1 EMBL· GenBank· DDBJ | mRNA | ||
GABF01007374 EMBL· GenBank· DDBJ | JAA14771.1 EMBL· GenBank· DDBJ | mRNA | ||
GABD01005933 EMBL· GenBank· DDBJ | JAA27167.1 EMBL· GenBank· DDBJ | mRNA | ||
GABE01008432 EMBL· GenBank· DDBJ | JAA36307.1 EMBL· GenBank· DDBJ | mRNA | ||
GABE01008431 EMBL· GenBank· DDBJ | JAA36308.1 EMBL· GenBank· DDBJ | mRNA |