K7CC05 · K7CC05_PANTR
- Protein[histone H3]-trimethyl-L-lysine(4) demethylase
- GeneKDM5C
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1560 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 3 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl4-[histone H3] + 3 succinate
3 CHEBI:16810 + RHEA-COMP:15537 CHEBI:61961 Position: 4+ 3 CHEBI:15379 = 3 CHEBI:16526 + 3 CHEBI:16842 + RHEA-COMP:15547 + 3 CHEBI:30031
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | chromatin remodeling | |
Biological Process | methylation | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-trimethyl-L-lysine(4) demethylase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionK7CC05
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-55 | JmjN | ||||
Sequence: CPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPP | ||||||
Domain | 79-169 | ARID | ||||
Sequence: TRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQS | ||||||
Region | 197-227 | Disordered | ||||
Sequence: LRQSVQPSKFNSYGRRAKRLQPDPEPTEEDI | ||||||
Compositional bias | 212-227 | Basic and acidic residues | ||||
Sequence: RAKRLQPDPEPTEEDI | ||||||
Domain | 324-374 | PHD-type | ||||
Sequence: SYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMA | ||||||
Domain | 468-634 | JmjC | ||||
Sequence: EYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYR | ||||||
Region | 1316-1371 | Disordered | ||||
Sequence: QAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGK | ||||||
Region | 1444-1560 | Disordered | ||||
Sequence: ERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL | ||||||
Compositional bias | 1461-1489 | Basic and acidic residues | ||||
Sequence: RKVDRGGEGDDPAREELEPKRVRSSGPEA | ||||||
Compositional bias | 1515-1541 | Polar residues | ||||
Sequence: GSPSTQENQNGLEPAEGTTSGPSAPFS |
Sequence similarities
Belongs to the JARID1 histone demethylase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,560
- Mass (Da)175,704
- Last updated2013-01-09 v1
- Checksum0AC0C59CB859CE2C
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3RBB1 | A0A2I3RBB1_PANTR | KDM5C | 1557 | ||
A0A2I3RJ03 | A0A2I3RJ03_PANTR | KDM5C | 1553 | ||
A0A2I3RN38 | A0A2I3RN38_PANTR | KDM5C | 1544 | ||
A0A2I3S3C0 | A0A2I3S3C0_PANTR | KDM5C | 99 | ||
H2QZD0 | H2QZD0_PANTR | KDM5C | 1257 | ||
A0A2I3T235 | A0A2I3T235_PANTR | KDM5C | 1516 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 212-227 | Basic and acidic residues | ||||
Sequence: RAKRLQPDPEPTEEDI | ||||||
Compositional bias | 1461-1489 | Basic and acidic residues | ||||
Sequence: RKVDRGGEGDDPAREELEPKRVRSSGPEA | ||||||
Compositional bias | 1515-1541 | Polar residues | ||||
Sequence: GSPSTQENQNGLEPAEGTTSGPSAPFS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACZ04001359 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AACZ04001360 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
GABC01004818 EMBL· GenBank· DDBJ | JAA06520.1 EMBL· GenBank· DDBJ | mRNA | ||
GABF01005693 EMBL· GenBank· DDBJ | JAA16452.1 EMBL· GenBank· DDBJ | mRNA | ||
GAQN01000001 EMBL· GenBank· DDBJ | JAB84757.1 EMBL· GenBank· DDBJ | mRNA |