K5X304 · K5X304_AGABU

Function

function

Converts sphingomyelin to ceramide.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

163250100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site150Zn2+ 1 (UniProtKB | ChEBI)
Binding site152Zn2+ 1 (UniProtKB | ChEBI)
Binding site221Zn2+ 1 (UniProtKB | ChEBI)
Binding site221Zn2+ 2 (UniProtKB | ChEBI)
Binding site260Zn2+ 2 (UniProtKB | ChEBI)
Binding site372Zn2+ 2 (UniProtKB | ChEBI)
Binding site406Zn2+ 2 (UniProtKB | ChEBI)
Binding site408Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Molecular Functionsphingomyelin phosphodiesterase activity
Biological Processsphingomyelin catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase

Gene names

    • ORF names
      AGABI1DRAFT_115230

Organism names

Accessions

  • Primary accession
    K5X304

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500389103022-632Sphingomyelin phosphodiesterase
Disulfide bond66↔77
Disulfide bond165↔170
Disulfide bond171↔194

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain144-409Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    632
  • Mass (Da)
    69,288
  • Last updated
    2013-01-09 v1
  • Checksum
    E7A1BC60BAE2C4F1
MKTSWLLTLAAAFCCIGGINADLVDDIVNAITHAVDCASCHALLLPLAGLALIGDGALTGTITAVCKALGVEDDDVCEGVIGDQGPILAHDLRSISPFGRTATLLCEATFGLCQAPAVNQFKFPLPAAPVNPKKWISSGREPFQVVHFSDVHIDRDYTPGAEVQCTKPICCRNWADAAGEPIKEAAGPIGSHSCDTSTSLIQSMLHAASIQENSFSIFTGDVIEADIWLVNQNGVTSNLKQFDEEMQTIMTNSVFPVMGNHDVAPVNSFPRNTSDGATSSQWAFDVQSSGWSKWLDASAIDSVQHMSGSYSILVPGRNLRVISMNDIYWYKANFWLFDSDNLQRDPNGILTFVAEQLQAAEDAGQRAWIIAHMPPNSGDALHDQSNYFDQIVRRYSNTIAGQFYGHTHRDEFGISYSDYDNRIAENAISTSWICPSTTPRSGNPAFKVYDVDPDTFEVMDARVFFSDMNDASFQTAPQWTQYYSAREVYGAAIPGGWPATTPLTPAFWHKVTEAFERDDNLFKKYLEFKNRGINVETCAPGACKDQALCQLRAGRSESNCQVTTPGLNFRRRDSEESHKHDGRHSTIDHCEGTGLGTILSQMPGKMAGANIEGLRQKLAEQSIQWEGVKHQT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH971396
EMBL· GenBank· DDBJ
EKM77297.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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