K5WK33 · K5WK33_AGABU
- ProteinAlpha-aminoadipate reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1437 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
Catalytic activity
- (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP+ = L-2-aminoadipate + ATP + NADPH + H+
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-aminoadipate-semialdehyde dehydrogenase activity | |
Molecular Function | phosphopantetheine binding | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-aminoadipate reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Agaricineae > Agaricaceae > Agaricus
Accessions
- Primary accessionK5WK33
Proteomes
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 878-955 | Carrier | |||
Sequence similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,437
- Mass (Da)157,027
- Last updated2013-01-09 v1
- Checksum4FED19677CB2EA32
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JH971410 EMBL· GenBank· DDBJ | EKM75626.1 EMBL· GenBank· DDBJ | Genomic DNA |