K5WK33 · K5WK33_AGABU

Function

function

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Catalytic activity

Cofactor

pantetheine 4'-phosphate (UniProtKB | Rhea| CHEBI:47942 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.

GO annotations

AspectTerm
Molecular FunctionL-aminoadipate-semialdehyde dehydrogenase activity
Molecular Functionphosphopantetheine binding
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-aminoadipate reductase
  • EC number
  • Alternative names
    • L-aminoadipate-semialdehyde dehydrogenase

Gene names

    • ORF names
      AGABI1DRAFT_79561

Organism names

Accessions

  • Primary accession
    K5WK33

Proteomes

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain878-955Carrier

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,437
  • Mass (Da)
    157,027
  • Last updated
    2013-01-09 v1
  • Checksum
    4FED19677CB2EA32
MAERLTRVVSRLQSLPSISLPTDYPRPAGSNKLIEAAHAAELSGTVATSLMRLALYTEDENGDDDDEGPHVQQPSAFHLLLAAFVVLLHRFTGDTDIVIGSSSATARDPLVLRLAVDPLESFWAIVRSVQRIEAEAEADAVPFEDLTRALSKGGDGLEAPIFRVRFFDETDEPKDNFIRTTNLTSDLTIFITRPPATTRTALAPRLSLKILYNSLLFSQTRISYIIDQLSVLLRKVSTNPLAPVGSVPLITPSQKSILPNPTADLDWCGWKGAITDVFSLNARTMPERPCVIQSIPAPTLEEPQTTITYTYGQIRRAANILAHHLIAGGVQREEVVMVYAHRSVDLVVAVMAVLKAGATFSVIDPAYPASRQTIYLQVAQPRGLVVLKGAGQINPTVRDFLSAELKIRVEVPALEILPDGTLNGGTGLEGQDVLAQHLPLADVDPNVTLGPDSIGTLSFTSGSTGIPKGVKGRHYSLTHFFPWMGQRFGLSKDSKFTMLSGIAHDPIQRDIFTPLFFGAQLHVPTADDIGTPGRLAEWMANTGVTVTHLTPAMGQLLSAQATRQIPDLQNAFFVGDILTKRDCLRLQSLAANVRIINMYGTTETQRAVSYFAIPPLSEDSSFLATQKDVMAAGQGMIDVQLLVVNRNDRNIPCAIGEVGEIYVRSGGLAEGYLDPTATTEKFVMNWFSDGAPPRQDTVLHPIQGLAGPESRYWRGIRDRMYRSGDLGRYLPDGTVECTGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKDEEKILISYVVPLDGPNLDGFASEIPDDEEGKGLVAGMKRYRCLIKNIREHLKTKLPSYSVPSIIVPLKRMPLNPNGKIDKPALPFPDTAQASHVATSSQTANPTEQKMQSIWASILPNAPTPIPLNESFFDLGGHSILATRLIFEMRKVFVVNAPLGLIFEQPTIAGLVAAVDTLRNADLGLNYQEPTRLGAGANGQLSGNGIQKTMVAPLEYGQDYIELLEKLKPSYPSLPSDFYDHSVTVFLTGATGFLGAFVLKDLLSREERVKKVICLVRGSDQDQALRRLKNGSTDRGVWDDKWVQEGRLEVVTGDLGLEAFGLTSGTWNKVAAEADVILHNGALVHWVYPYERLRAPNVIATLTAMDLASSGKPKSFVFVSSTSAVDTEHYVNLSETFALGRSDYQGIPENDDLEGAKINLKTGYGQSKWVSEKLLFEAGKRGLNGHIVRPGYVVGDSRTAVTNTDDFICRLIKGCIQLGLIPDINNTVNMVPVDHVALCTSLAAISPLQNNASLSVLHIQAQPLPTFNTMLTALAKYGFSTEPCEYLVWRRKLEQHVMETQDNALFPLLHFVLDDLPTSTKAPALDDRNTAELLERAKGERNGGEEEGSASRTVNDELMGLYLAWLVGAEFLPRPSAENPERALPKLSIEGVIKAAGRSGV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH971410
EMBL· GenBank· DDBJ
EKM75626.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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