K5W3F1 · K5W3F1_AGABU

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-18GTP (UniProtKB | ChEBI)
Active site13Proton acceptor
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site13-16IMP (UniProtKB | ChEBI)
Binding site38-41IMP (UniProtKB | ChEBI)
Binding site40Mg2+ (UniProtKB | ChEBI)
Binding site40-42GTP (UniProtKB | ChEBI)
Active site41Proton donor
Binding site135IMP (UniProtKB | ChEBI)
Active site146
Binding site149IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site226IMP (UniProtKB | ChEBI)
Binding site241IMP (UniProtKB | ChEBI)
Binding site301-307substrate
Binding site305IMP (UniProtKB | ChEBI)
Binding site307GTP (UniProtKB | ChEBI)
Binding site333-335GTP (UniProtKB | ChEBI)
Binding site415-417GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      AGABI1DRAFT_106065

Organism names

Accessions

  • Primary accession
    K5W3F1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    47,335
  • Last updated
    2013-01-09 v1
  • Checksum
    8F1665BD7E12D349
MSVTVVLGSQWGDEGKGKLVDILSAEIDVCARCAGGNNAGHTIIVPIGPERVPTTFAFHLLPSGLINPSCTGVIGSGVVIHVPSFFQELDALQSKGLDCTNRLFISDRAQLVFDFHQIVDGLKEIELGGSSIGTTKKGIGPAYSGKASRSGLRVHHLFDHTNFATKFRHIVEGRFKRYGHFEYDTEGEIERYKLLAERLKPYVIDSVVYIHKAISQGKRVLVEGANALMLDLDFGTYPYVTSSSTTIGGVCTGLGIPPKMIGKTIGVVKAYTTRVGGGPFPTEQLNDIGVHLQEIGREFGSTTGRRRRCGWLDLVVLKHSCWINGYDTFNLTKLDILDQLSEIKVAIAYKIDGKELDGFPADLDILDRVEVEYVTLPGWKSSIADTKTYEDLPDNCRKYVEFIEDHIGVPIEWIGVGPERESMVKKECKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH971388
EMBL· GenBank· DDBJ
EKM81324.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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