K5VP82 · K5VP82_AGABU

Function

function

Proteolytically removes the C-terminal three residues of farnesylated proteins.

Catalytic activity

  • Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.
    EC:3.4.24.84 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

146250100150200250300350400450
Type
IDPosition(s)Description
Binding site303Zn2+ (UniProtKB | ChEBI); catalytic
Active site304
Binding site307Zn2+ (UniProtKB | ChEBI); catalytic
Binding site386Zn2+ (UniProtKB | ChEBI); catalytic
Active site390Proton donor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological ProcessCAAX-box protein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CAAX prenyl protease
  • EC number

Gene names

    • ORF names
      AGABI1DRAFT_78691

Organism names

Accessions

  • Primary accession
    K5VP82

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane125-154Helical
Transmembrane175-195Helical
Transmembrane201-220Helical
Transmembrane316-337Helical
Transmembrane357-381Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-230CAAX prenyl protease 1 N-terminal
Domain234-452Peptidase M48

Sequence similarities

Belongs to the peptidase M48A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    462
  • Mass (Da)
    52,852
  • Last updated
    2013-01-09 v1
  • Checksum
    3FDC50BB423514FC
MDILHNQLQAVQRSLSFVSTDPIDWKFYVQVFAWSVTLFESYLITRQYPLYSKTEPPKALQGHFEKGEFEKSQAYGKDKARFAFVSGLYKQTLDSLMLQFGFYAWSWQAAGSLLAKFGYGTEHQIIQSIGFVFILFFVSSLPTLPLQVYGTFVLEEKHGFNKTTPKLFVTDLLKGWAIAFVLGAPFLAVFLYIFEWAGDRFVPWLMAFMITFQLSMVILYPTVIQPLFNKLSPLSEGDLRNRIEALAVKLKFPLKHLYEIDGSKRSSHSNAYFFGLPWSKHIVIFDTLIQQSKPEEVEAVLAHELGHWYYLHPTKLMAVSQLHIFTILALFPAFLHAPPLLSAFDFSKGVAAAPPTIVAFLLFQMILTPLEAVISIGMNAVSRQFEWEADKFAVELEEKLNEKDMGDMGDRLGKALITLHVKNLSTVWVDWLYSAYHHSHPTLTERLRALEGFAEEKRKKST

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH971403
EMBL· GenBank· DDBJ
EKM76274.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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