K4PCW8 · K4PCW8_9RHAB
- ProteinReplicase
- GeneL
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2129 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- GTP + H2O = GDP + H+ + phosphate
- a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
- a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + S-adenosyl-L-homocysteine
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity | |
Molecular Function | RNA-dependent RNA polymerase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReplicase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Alpharhabdovirinae > Sigmavirus > Sigmavirus melanogaster
Accessions
- Primary accessionK4PCW8
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 598-785 | RdRp catalytic | ||||
Sequence: LTITDHIDYEKWNNHQRGEANNPIFLVMGKFLGYPHLIERTHEIFEKSWIYYLNRADLMDFDGEGNLMNRTELRVCWNGQKGGLEGLRQKGWSICNLLVLRRESLATNTVVKTLAQGDNQVLSSRYRIRTSRDQNQLQSNIEDICRNNRSLMERIRIGTGKLGLIINHDETIKSTEYMNYGKTCVIHG | ||||||
Domain | 1654-1851 | Mononegavirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: RTAQIATGSHYKLRSILSKLRLNVRGALVGGDGSGGLTALVCRMYPTSRVIFNSICDFSDVRLKGTTPAPPSALSHSLNDCTQVVNYSDSWAHPSDLTDTKTWKYFVDITKSKSIQVDLIILDMEVVDESSISKIEDNLMRYGPQLLTRDGVILFKTYLTRIFKAQEMILTKCGHVFSQVELWYSDLSSSQTSEVYVL |
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,129
- Mass (Da)241,202
- Last updated2013-01-09 v1
- ChecksumEA68BF2269723175