K4PCW8 · K4PCW8_9RHAB

Function

Catalytic activity

  • GTP + H2O = GDP + H+ + phosphate
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + 2 S-adenosyl-L-homocysteine
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + S-adenosyl-L-homocysteine
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      L

Organism names

  • Taxonomic identifier
  • Strains
    • G0A_415
    • G0B_415
    • H_415
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Alpharhabdovirinae > Sigmavirus > Sigmavirus melanogaster

Accessions

  • Primary accession
    K4PCW8

Subcellular Location

Cytoplasm
Host cytoplasm
Virion

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain598-785RdRp catalytic
Domain1654-1851Mononegavirus-type SAM-dependent 2'-O-MTase

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,129
  • Mass (Da)
    241,202
  • Last updated
    2013-01-09 v1
  • Checksum
    EA68BF2269723175
MDFEIEDPYDPFSMDTYLDPQDPSFGDLESMRHLSNVDYSLNSPMIADELEAFIRWLQCGCTDPRWNEDRWVRTKQGLFSGQSPTTIEGAATFTGWFGNFNLKRRYYIVRQFKMILEKAQADSEETKPVVDAFLRGWINHKGVTLTSKITLPEEELKWGYYFWELHIVTLHLNCTTDQERTHLIKSFKSKSRGLPDVFDFTLYTRNFGPLSIAGGYVYMFDHNRMLDRNAILMMKDTYVARFNSFLALSNRADCVFPEDAHYRLQMLYEIGDMVLDEGGTSGYNGLKLLEAMCSSRITDLAQSKKPLIPDFPDFRSHVRAKVREESANTPSIGKMYELIEGTTSYDTLLTFYGSFRHWGHPYINYLAGLEKLYIQTTVEKEIDQEYVEKLASDLAFLIIQDRFRKTKKWPVDPLLIDKDHPLVEYIRTSSWPNNSIIKNFGDGWHTLPLTKCYDIPDVIDPSLLYSDKSHSMTRSEVRGWMTSHPGKPIPSRKVLSTLLNSPSTNWPVFLQQVNDSGIPIEQLIIGLMAKEREQKIDGRFFSLMSWDIRDYFVMTEYLIKTHFVPLFKGLTMADDLTTVIGKILENSRGQGEADYENLTITDHIDYEKWNNHQRGEANNPIFLVMGKFLGYPHLIERTHEIFEKSWIYYLNRADLMDFDGEGNLMNRTELRVCWNGQKGGLEGLRQKGWSICNLLVLRRESLATNTVVKTLAQGDNQVLSSRYRIRTSRDQNQLQSNIEDICRNNRSLMERIRIGTGKLGLIINHDETIKSTEYMNYGKTCVIHGNIRNLETKRWSRVTCVTNDQLPTLSNVMATIGSNALTVSHYSDSPINSMYHYNFMGNFVRIMNEIHNPALRGPVSSIEGVTGQSFSRLSYLLAVLYLDPSMGGACGMSLTRFLIRMFPDPITESLTFLRIVAMNVHSDEVRQTFIQFGNPKLKTFSPEDLSKLLEDPLSINVPKGLSATNLIKDAIKLSLHRSVDEIANEIIAEAVIHQKDHEEGFLMHLTQISPLFPRFLSEYKAGTYLGIAEGLIGLFQNSKTIRNQFRRNLDIGYDSIVIKSEIATIRDLTGYRLEDAERVEMWPCSSTQADYLRRVSWQQVVYGATIPHPAELFGLPLRAAPTCPNCTTTFPMNLYISVLIPLGFKGLKDTRGTCVAYLGSSTTESTGIVNPWEKEAVVPVIKRAASLRNGIGWFIEPGSNLAQSILNNLQSLTGESWSQNSGGVRRTGSALHRFSCSRQSGGGYTAQNPSKLTRMIATTNYLADLGDENYDFMYQSCLLNALISVGEIHPVDGSQGYYHQHVNCTSCLRPIKEVTLESPAPYSHTITSNLLDKWKPDGSKWSVSRPSIPLRSGKWECVSHDRQSYHVGFIQGFIYGDSVWGIRSMADDPALFPLSFRNKVNPRAYLLGILHGLLRSCTVSVVHQRCFRSSRAVKQTTLGLCSMTVSRLVQNDGFLNILRDEQFTAVFRSIPHRIPPSYPMVTQDIGDLASNYLKRQLMTEGLAYFRSVKSGSGNEAWIFADANHPMIVSLITVSGLMTKILAKDIWQKRDLEELKELRSLSVQAREQDDPHTDITAMESLAAEWVVCSDQETRHAVKYNTRIESVTDSGLTVTWGDEYTSSADFVTVVFSVEEIRTPPGMLIPRIQNPLISGLRTAQIATGSHYKLRSILSKLRLNVRGALVGGDGSGGLTALVCRMYPTSRVIFNSICDFSDVRLKGTTPAPPSALSHSLNDCTQVVNYSDSWAHPSDLTDTKTWKYFVDITKSKSIQVDLIILDMEVVDESSISKIEDNLMRYGPQLLTRDGVILFKTYLTRIFKAQEMILTKCGHVFSQVELWYSDLSSSQTSEVYVLMSGQTKLSHLQVRKPDLMQLRTDVSSFPVFAPPIVEFKRARKVAGLDLTVGVPPLLLPEPGPEMINLLSSLGVRPDISFSITRSFGDNMSTEFLPLHLFLLALNGIYDVTTGYRTPPGPPSDQVCIKLGIWIVGYRIWSGYVQDSYAKASFGQKLIDNFVPFNFWNKQIGRSWFPHWSLIKPQTYTKNIQLDSEMAHIGSVIRILHRNFPKARRNPPGDLVDNNCSRINKGISCLNMDMKTGILRWMGDGRDLSGVNVTTRISNFYVTQDDQTASFRN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX403912
EMBL· GenBank· DDBJ
AFV52413.1
EMBL· GenBank· DDBJ
Viral cRNA
JX403919
EMBL· GenBank· DDBJ
AFV52454.1
EMBL· GenBank· DDBJ
Viral cRNA
JX403926
EMBL· GenBank· DDBJ
AFV52494.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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