K4MJ40 · K4MJ40_SIV

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

110151002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding945-992Integrase-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Organism names

Accessions

  • Primary accession
    K4MJ40

Proteomes

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-60Disordered
Compositional bias20-34Polar residues
Compositional bias41-56Basic and acidic residues
Domain84-153Peptidase A2
Domain207-397Reverse transcriptase
Domain596-719RNase H type-1
Domain725-766Integrase-type
Domain775-926Integrase catalytic
Domain945-992Integrase-type
Region993-1015Disordered

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,015
  • Mass (Da)
    115,037
  • Last updated
    2013-01-09 v1
  • Checksum
    5F92A5C40653C790
FFRVWPLGKEAPQFPHGPNASGADANSSPSGPSGGSAEELHEDGSGTEREQEEALQGGDRGLAAPQFSLWRRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGPNYTPKIVGGIGGFINTKEYKNVEIKVLGKKIKGTIMTGNTPINIFGRNLLTTMGMSLNCPIAKVEPVKVTLKPGKDGPKLRQWPLSKEKIIALREICEKMEKEGQLEEAPPTNPYNTPTFAIRKKDKNKWRMLIDFRELNKVTQDFTEVQLGIPHPAGLAKRRRITVLDVGDAYFSIPLDENFRQYTAFTLPSVNNAEPGKRYIYKVLPQGWKGSPAIFQYTMRNVLEPFRKANPDVTLIQYMDDILVASDRTDLEHDRVVLQLKELLNSTGFSTPDEKFQKDPPFKWMGYELWPTKWKLQKIELPQRETWTVNDIQKLVGVLNWAAQVYPGIKTKHLCKLIRGKMTLTEEVQWTEMAELEYEENKIILSQEQEGCYYQEGKPLEATVIKNQDNQWSYKIHQEDKILKVGKFAKIKNTHTNGVRLLAHVIQKIGKEAIVIWGQIPKFHLPVERDVWEQWWTDYWQVTWIPEWDFVSTPPLVRLVFNLVKDPIKGEETYYVDGSCNRQSKVGKAGYITDRGKDRVKILEQTTNQQAELEAFLMALQDSGPKANIIVDSQYVMGIVTGCPTESESRLVSQIIEEMIKKEEIYVAWVPAHKGIGGNQEIDHLVSQGIRQVLFLEKIEPAQEEHERYHSNVKELVFKYGIPRLVAKQIVDTCDKCQQKGEAIHGQVNSDLGTWQMDCTHLEGKVIIVAVHVASGFIEAEVIPQETGRQTALFLLKLAGRWPITHLHTDNGANFTSQEVKMVAWWAGIEQTFGVPYNPQSQGVVEAMNHHLKNQIDRIREQANSVETIVLMAVHCMNFKRRGGIGDMTPAERLINMITTEQEIQFQQSKNSKFKNFRVYYREGRDQLWKGPGELLWKGEGAVILKVGTDIKVVPRRKAKIIKDYGGGKEMDSGPHVEDSGEAREVA

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias20-34Polar residues
Compositional bias41-56Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX860429
EMBL· GenBank· DDBJ
AFV26266.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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