K4M3W7 · K4M3W7_9CNID

  • Protein
    NADH:ubiquinone reductase (H(+)-translocating)
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular FunctionNADH dehydrogenase (ubiquinone) activity

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH:ubiquinone reductase (H(+)-translocating)
  • EC number

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Octocorallia > Scleralcyonacea > Primnoidae > Parastenella

Accessions

  • Primary accession
    K4M3W7

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane49-66Helical
Transmembrane78-102Helical
Transmembrane129-151Helical
Transmembrane163-181Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-89NADH dehydrogenase subunit 2 N-terminal
Domain92-188NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    188
  • Mass (Da)
    20,279
  • Last updated
    2013-01-09 v1
  • Checksum
    09B52D2E44E7C45E
MELTLGLIILIVLMYGLKAPTLRLATFCLGVILLMSAVGAEPHLLCWTQAIKMLVMLSGLAILCMLDHRTSHRSSSLLILLVILGNLLLIGSTNLISIYLALEMQTLCMFILVAYNKNSLLSAEAGLKYFVLGALSSGLFLFGCALIYGSTGELELQFIRMSLISYGALAGKCLITVSLLFKVSAAPF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue188

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX561195
EMBL· GenBank· DDBJ
AFV15235.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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