K2QWF1 · K2QWF1_MACPH

Function

function

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide.
    EC:3.4.14.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

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Type
IDPosition(s)Description
Active site310Charge relay system
Active site314Charge relay system
Active site532Charge relay system
Binding site574Ca2+ (UniProtKB | ChEBI)
Binding site575Ca2+ (UniProtKB | ChEBI)
Binding site593Ca2+ (UniProtKB | ChEBI)
Binding site595Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    tripeptidyl-peptidase II
  • EC number

Gene names

    • ORF names
      MPH_08824

Organism names

Accessions

  • Primary accession
    K2QWF1

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_500386340017-617tripeptidyl-peptidase II

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain225-615Peptidase S53
Region288-309Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    617
  • Mass (Da)
    67,727
  • Last updated
    2012-11-28 v1
  • Checksum
    5BBA0862114CAF75
MLGFLLVLLLMLGASASTLRPRAGYSVKDTFDAPASWSRIGPAPSDHVIHLHIGLKQGDFAELERHLYEVSDPHHERYGQHMSAEEVNELVKPADQTLDLVHEWLEENGILKTHLAYSPAKDWIKIALPVNRVEALLNAEYSVYEHESGDHLVRTSQWSLPHHLHEHVEAIQPTNSFFRTAPRTSYVKRVIEGKTQPLVQRKPNPVQSASSSHVLDVSHKCNSSWVTPDCLRTYYGIFDYAPRVPAKNSIGLVNFLNQTSKRTDVKAFLQQFRKEAVSAADQFTIEIVNGGDDTQTPNTEEQNNQTKNSEGDLDAELILSLGHPTPLIAYNTGGFAADFTPDAFYPENHNEPFLAWALHVLKKDDKDIPHVISSSYGDFEHTVPYDFAKKICDQFAQLAARGVSLLFPSGDLGVGPSGYCYSNDGRNASTFIAMFPASCPYVTAVGATAGFAPEVAAKDEDMPFFRSGGGFSRYFAQPNWQADAVSRYLKTHEGIEADLYNKSGRAYPDIAAQGQSIVHTWEGNTTALYGTSASVPIAATIIALVNDALIQAGRPALGFLNPWLYKSGSKFFHDIVDGDSAGCNTTGFPATVGWDPVTGVGSPNFTAVLAGLDLQMW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AHHD01000375
EMBL· GenBank· DDBJ
EKG14081.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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