K2AUH6 · K2AUH6_9BACT

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-16substrate
Active site72Proton acceptor
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site73substrate
Binding site157-160substrate
Binding site180substrate
Binding site185-186substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      ACD_46C00142G0001

Organism names

Accessions

  • Primary accession
    K2AUH6

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    23,008
  • Last updated
    2012-11-28 v1
  • Checksum
    838DAF6F6A27F97F
MLDDPKIVIASSNAGKVAELLSLLETLPVEWIPQQRFDIPDALETGKTFIENAILKARHAAKLSGLPALADDSGLMVDALDGAPGVYSARYAGENASNADRIQKLLQAMQNVEADDRGANYHCILALVQHENDPAPLIFHGFWEGEILFEVRGQHGFGYDPIFYVPTHGCSAAEMNPLEKNLISHRGQAVAQLLEIFEAADHYDDTAANDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AMFJ01019562
EMBL· GenBank· DDBJ
EKD71625.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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