Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

K0ZH94 · K0ZH94_9STRE

Function

function

Catalyzes the conversion of lactate to pyruvate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site14-19NAD+ (UniProtKB | ChEBI)
Binding site18NAD+ (UniProtKB | ChEBI)
Binding site39NAD+ (UniProtKB | ChEBI)
Binding site46NAD+ (UniProtKB | ChEBI)
Binding site71NAD+ (UniProtKB | ChEBI)
Binding site85-86NAD+ (UniProtKB | ChEBI)
Binding site88substrate
Binding site94substrate
Binding site101NAD+ (UniProtKB | ChEBI)
Binding site107NAD+ (UniProtKB | ChEBI)
Binding site124-126NAD+ (UniProtKB | ChEBI)
Binding site126-129substrate
Binding site149NAD+ (UniProtKB | ChEBI)
Binding site154-157substrate
Binding site159beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site174beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site181Proton acceptor
Binding site235substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • ORF names
      GMD6S_04005

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GMD6S
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    K0ZH94

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue226Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-148Lactate/malate dehydrogenase N-terminal
Domain151-316Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    35,283
  • Last updated
    2012-11-28 v1
  • MD5 Checksum
    09A6503751773C6F411A8BC6ACC3AC50
MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLHEKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFDGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELFEGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVKNVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQAASKN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJRH01000015
EMBL· GenBank· DDBJ
EKA06539.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help