K0Q6T4 · K0Q6T4_BRAFL

Function

function

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.

Catalytic activity

  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
    EC:3.2.1.18 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlysosomal lumen
Cellular Componentlysosomal membrane
Molecular Functionexo-alpha-(2->3)-sialidase activity
Molecular Functionexo-alpha-(2->6)-sialidase activity
Molecular Functionexo-alpha-(2->8)-sialidase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sialidase-1
  • EC number
  • Alternative names
    • Lysosomal sialidase
    • N-acetyl-alpha-neuraminidase 1

Gene names

    • Name
      LOC118421326

Organism names

Accessions

  • Primary accession
    K0Q6T4

Proteomes

Subcellular Location

Lysosome membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-34Helical

Keywords

  • Cellular component

Interaction

Subunit

Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain105-381Sialidase

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    48,495
  • Last updated
    2012-11-28 v1
  • Checksum
    9553D7FA1821236C
MTDIKQASAMLKWLRVVLRVLLVIMVLMTGRLLYSRVSYSTLTKRQMDLHNDAQTAQGSSVQRSPRSSNAGVSLSVVHDIVLWTSHRRGEVGIFRVPVLTYTPKGNLVAITEGRRKSKSDENPKVFAVKRSTDGGATWSPSQWIVDDGMSRFKRCSYIGTIFVDDTTATIFLMYVFCEFCPTRSLMLMNSTDDGITWGRPRNITDQVGKEHATHPSPGYGIQKKHDPAKGRLIVCGHGFHDGKGLVLLLSDDHGVTWRHGAFVPSVPFLNIQKGHFDPDECQPVEFPDGSVHIVVRNQMVYKCNCKMIMRSFDGGETLPRQYMLLDRTLIEPRITSGVWLHNGTMFYSGPNTRLKRSKLYIRWSHDFGRTWTSGTEIWGDLAGYSTFTMLPQDNDHIYMLYERGTTEYFDEIAVTKLKISSSTTHDPR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BK008527
EMBL· GenBank· DDBJ
DAA35214.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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