K0P313 · K0P313_HASOS

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • NCC 392
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Ochrophyta > Bacillariophyta > Bacillariophyceae > Bacillariophycidae > Naviculales > Naviculaceae > Haslea

Accessions

  • Primary accession
    K0P313

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-84Helical
Transmembrane96-123Helical
Transmembrane143-167Helical
Transmembrane179-203Helical
Transmembrane215-237Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_500383816429-240Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-240Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    240
  • Mass (Da)
    26,162
  • Last updated
    2012-11-28 v1
  • Checksum
    3477E5EC61C3874C
GAPDMAFPRMNNISFWLLPPSLLLLVESILCEAGVGTGWTVYPPLSGITAHSGGSVDLAIFSLHLSGAASILGAISFICTIVNMRTKNLAFHRLPLFVWSIFITAILLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGIISHIVVSASRKPIFGYLGMVYAMLSIGILGFIVWAHHMYTVGLDIDTRAYFTAATMIIAIPTGIKVFSWLATLW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue240

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE995427
EMBL· GenBank· DDBJ
CCM44533.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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