K0KEG4 · K0KEG4_SACES

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site775-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1025-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site129-1375-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site192uracil (UniProtKB | ChEBI)
Binding site197-199uracil (UniProtKB | ChEBI)
Binding site1985-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      BN6_77120

Organism names

Accessions

  • Primary accession
    K0KEG4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    22,161
  • Last updated
    2012-11-28 v1
  • MD5 Checksum
    A6D90452EA74AD5D89178FBD2CFB0DA7
MDVLVVEHPLARARLTTMRDARTDNAAFRAALHELTVMLVYEATRNSPVAEEKVHTPVARTTGYRLENPPLLVPVLRAGLGMADQAHKLIPDAQMGFVGLARDEETLQPTPYMESLPESLAGRPVLVLDPMLATGGSMVYTIRLLTDRGATDVTAVCALAAPEGIKHLADSGLPVRLVTASVDERLNDSGFIVPGLGDAGDRQYGAV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE804045
EMBL· GenBank· DDBJ
CCH34933.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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