K0KAX6 · K0KAX6_SACES

Function

function

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.

Pathway

Nitrogen metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site137heme b (UniProtKB | ChEBI)
Binding site230heme b (UniProtKB | ChEBI)
Binding site263Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxynitrite isomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxynitrite isomerase
  • EC number
  • Alternative names
    • Ferric nitrobindin
      (Nb(III)
      )

Gene names

    • Ordered locus names
      BN6_82040

Organism names

Accessions

  • Primary accession
    K0KAX6

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain117-270THAP4-like heme-binding beta-barrel
Motif125-131GXWXGXG

Domain

Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.

Sequence similarities

Belongs to the nitrobindin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    29,524
  • Last updated
    2012-11-28 v1
  • Checksum
    F87D3C399A1150C0
MRTGTGDPVFVSRCPPRPSLRDAPAINLTGGTLLHSPDDRGGVGRRLVLRVRGLPAVLRPALMTENSPVPGSGDAAVRAAATRAETTGARNLPQFDDLPVPADTANLREGPSLHDACLALLPLVGMWRGEGEVVYPTIDGPYRFGQQVTFAHDGRPFLFYEARSWLLDADGAVIRQAARETGFWRPQPDDTIEVLLAHNTGIMELYYGKPRSQTSWELGTDAVVRTTTAKDVTGAQRLYGIVNGGDLAYVEERAMVGQPLQPHTSAHLKRVVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE804045
EMBL· GenBank· DDBJ
CCH35421.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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