K0A1Z7 · K0A1Z7_IXOHE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    K0A1Z7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-49Helical
Transmembrane70-92Helical
Transmembrane112-137Helical
Transmembrane149-176Helical
Transmembrane209-227Helical
Transmembrane234-252Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-253Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    253
  • Mass (Da)
    27,670
  • Last updated
    2012-11-28 v1
  • Checksum
    608505A30C44D40B
ILIRTELGQPGSLIGNDQIYNVIVTAHAFIMIFFMVMPVMIGGFGNWLIPLMLGAPDMAFPRMNNLSFWLLPPSIFLLLNSSLVESGAGTGWTVYPPLSANMSHSGASVDMAIFSLHLAGISSILGAINFITTIINMRSPGMTMERMPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPILYQHLFWFFGHPEVYILILPGFGMVSHIICFHTGKKEPFGTLGMIYAMLAIGFLGFIV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue253

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX394197
EMBL· GenBank· DDBJ
AFS65066.1
EMBL· GenBank· DDBJ
Genomic DNA
JX394198
EMBL· GenBank· DDBJ
AFS65067.1
EMBL· GenBank· DDBJ
Genomic DNA
JX394199
EMBL· GenBank· DDBJ
AFS65068.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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