J9ZZT2 · J9ZZT2_HV1
- ProteinPol protein
- Genepol
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1003 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 938-985 | Integrase-type | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | DNA binding | |
Molecular Function | exoribonuclease H activity | |
Molecular Function | RNA stem-loop binding | |
Molecular Function | RNA-directed DNA polymerase activity | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA integration | |
Biological Process | DNA recombination | |
Biological Process | establishment of integrated proviral latency | |
Biological Process | proteolysis | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral genome integration into host DNA |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus
- Virus hosts
Accessions
- Primary accessionJ9ZZT2
Proteomes
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 27-47 | Disordered | |||
Domain | 76-145 | Peptidase A2 | |||
Domain | 199-389 | Reverse transcriptase | |||
Domain | 589-712 | RNase H type-1 | |||
Domain | 718-759 | Integrase-type | |||
Domain | 769-919 | Integrase catalytic | |||
Domain | 938-985 | Integrase-type | |||
Sequence similarities
Belongs to the retroviral Pol polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,003
- Mass (Da)113,882
- Last updated2012-11-28 v1
- MD5 Checksum6449347C9F04C0F9DD14B9E0BDA6D6E5
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JX390612 EMBL· GenBank· DDBJ | AFS63979.1 EMBL· GenBank· DDBJ | Genomic RNA |