J9ZZT2 · J9ZZT2_HV1

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

110031002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding938-985Integrase-type

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Gene names

    • Name
      pol

Organism names

Accessions

  • Primary accession
    J9ZZT2

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region27-47Disordered
Domain76-145Peptidase A2
Domain199-389Reverse transcriptase
Domain589-712RNase H type-1
Domain718-759Integrase-type
Domain769-919Integrase catalytic
Domain938-985Integrase-type

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,003
  • Mass (Da)
    113,882
  • Last updated
    2012-11-28 v1
  • MD5 Checksum
    6449347C9F04C0F9DD14B9E0BDA6D6E5
FFRETLAFPQGEAREFYSEQARANSPTRRELQAWGGDNNSTSEAGADRQRTISFSFPQITLWQRPLVTIEIEGQLKEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYDQVLIKICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNFPISPIDTVSVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRKNPEIVIYQYMDDLYVGSDLEIGQHRTKIEELRAHLMNWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAELELAENREILKTPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSAHTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTPPLVKLWYQLEKDPIVGAETFYVDGAASKETKXGKAGYVTDRGRQKVVSLTETTNQKTELHAIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESEVVNQIIEELIKKDKVYLSWVPAHKGIGGNEQVDKLVSAGVRXVLFLDGIDKAQEEHERYHSNWRTMVSDFNLPPVVAKEIVANCDKCQLKGEAMHGQVDCSPGIWQVDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQDTAYFLLKLAGRWPVKVIHTDNGSNFTSAAVKAACWWANIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIASDIQTXELQKQITKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVADRQDED

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX390612
EMBL· GenBank· DDBJ
AFS63979.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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