J9VX37 · CTR1_CRYNH
- ProteinCUF1-dependent copper transporter 1
- GeneCTR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids288 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
High affinity copper transporter involved in Cu+ import into the cell upon copper-limitating conditions (PubMed:21819456, PubMed:23498952, PubMed:31932719).
Functions with BIM1 and probably also FRE4 and FRE7, where FRE4 and FRE7 metalloreductases liberate the Cu2+ bound to the BIM1 copper-binding site for subsequent import of Cu+ into the cell by CTR1, via the reduction of BIM1-bound Cu2+ to Cu+ to reduce binding affinity for BIM1 but increase affinity for CTR1 (Probable). The BIM1-CTR1 pathway for copper uptake plays a key role in colonization in the brain where copper amounts are low and thus in cryptococcal meningitis (PubMed:25417972, PubMed:31932719).
Functions with BIM1 and probably also FRE4 and FRE7, where FRE4 and FRE7 metalloreductases liberate the Cu2+ bound to the BIM1 copper-binding site for subsequent import of Cu+ into the cell by CTR1, via the reduction of BIM1-bound Cu2+ to Cu+ to reduce binding affinity for BIM1 but increase affinity for CTR1 (Probable). The BIM1-CTR1 pathway for copper uptake plays a key role in colonization in the brain where copper amounts are low and thus in cryptococcal meningitis (PubMed:25417972, PubMed:31932719).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | copper ion transmembrane transporter activity |
Names & Taxonomy
Protein names
- Recommended nameCUF1-dependent copper transporter 1
- Short namesCopper transporter 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus neoformans species complex
Accessions
- Primary accessionJ9VX37
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-62 | Helical | ||||
Sequence: MPSSAGATVGVCIGLFILAIF | ||||||
Transmembrane | 251-271 | Helical | ||||
Sequence: LLMLVVMTFNIWWMISVVIGC |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Leads to a severe growth defect in copper deficiency conditions, but does not significantly affect melanin production, nor fungal virulence (PubMed:21819456, PubMed:25417972).
However, when both CTR1 and CTR4 are disrupted, the colonization in the brain and subsequent virulence are significantly reduced (PubMed:25417972).
However, when both CTR1 and CTR4 are disrupted, the colonization in the brain and subsequent virulence are significantly reduced (PubMed:25417972).
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000449517 | 1-288 | CUF1-dependent copper transporter 1 | |||
Sequence: MDMSGMDGMDHMSSTSSNMSMSMKMYFHGTIGGDLLWFASWMPSSAGATVGVCIGLFILAIFERYLVAFRRACDAAWRRGQVGYVRPCSNGPLVFSSGKSTSLPPPVLFNRRSSTKKEKDVYNPLTPSDYALESNQDGSVEPVTPYTPSIHALRESQEGSSAPSYAHSQQGQAQAQGSGVGCDPCAEGRVAEIERCKEKAVERGLVHSHLPKAVRRSLDPGREGRWSRPFRLAVDVPRGLLQALQTLIHYLLMLVVMTFNIWWMISVVIGCGVGEMLFGRFGSSHVGH | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Induction
Expression is induced by copper deficiency and regulated by the CUF1 copper-dependent transcription factor (PubMed:21819456, PubMed:29608794).
The CTR1 promoter harbors the Cu-responsive element (CuRE), which is critical for CUF1 binding and activation under copper-limiting conditions (PubMed:29608794).
The CTR1 promoter harbors the Cu-responsive element (CuRE), which is critical for CUF1 binding and activation under copper-limiting conditions (PubMed:29608794).
Interaction
Subunit
Interacts with the copper acquisition factor BIM1.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 106-125 | Disordered | ||||
Sequence: PVLFNRRSSTKKEKDVYNPL | ||||||
Compositional bias | 154-177 | Polar residues | ||||
Sequence: RESQEGSSAPSYAHSQQGQAQAQG | ||||||
Region | 154-180 | Disordered | ||||
Sequence: RESQEGSSAPSYAHSQQGQAQAQGSGV |
Sequence similarities
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length288
- Mass (Da)31,538
- Last updated2013-11-13 v2
- ChecksumF6645FB118262C1D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 154-177 | Polar residues | ||||
Sequence: RESQEGSSAPSYAHSQQGQAQAQG |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003826 EMBL· GenBank· DDBJ | AFR96280.2 EMBL· GenBank· DDBJ | Genomic DNA |