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J9SNJ7 · J9SNJ7_9ACTN

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    ftsH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1808100200300400500600700800
Type
IDPosition(s)Description
Binding site206-213ATP (UniProtKB | ChEBI)
Binding site428Zn2+ (UniProtKB | ChEBI); catalytic
Active site429
Binding site432Zn2+ (UniProtKB | ChEBI); catalytic
Binding site504Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      KTR9_3945

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KTR9
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    J9SNJ7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane112-133Helical

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain198-337AAA+ ATPase
Region617-808Disordered
Compositional bias641-655Pro residues
Compositional bias668-738Pro residues
Compositional bias794-808Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    808
  • Mass (Da)
    87,646
  • Last updated
    2012-11-28 v1
  • MD5 Checksum
    6F49862F6D198FF28C10AEF038F7CEDA
MNRKTVFRNLAILALILLALWGWSVMSDSGREYRGVDTSVALQQLNDKNTKFVSIDDREQQLRIELKSPIKVNDADAGKISAKYPAQAGDQVFEAVQGTGAPYTTNVNEQSVLWQILIFVLPMILLFGLFFFVMSRMQGGGRGGVMGFGKSKAKQLSKDMPKTTFADVAGADEAVEELYEIKDFLQNPARYQALGAKIPRGVLLFGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKNNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRSGVILIAATNRPDILDPALLRPGRFDRQIPVGNPDMAGRRAILKVHAKGKPIDPDADLDGLAKRTPGMSGADLANVVNEAALLTARENKQTITAEALEEAVDRVIGGPRRKSRIISEHERKVVAYHEGGHTLAAWAMPDLAPIYKVTILARGRTGGHALAVPEQDKDLMTRSEMIARLVMAMGGRAAEELVFHEPTTGASSDIDQATKIARAMVTEYGMSSKLGAVRYGQDQGDPFLGRSMGSHTDYSAEIASEIDDEVRRLIEAAHTEAWAILTEYRDTLDVLATQLLEKETLTRKDLEKIFSDVDKRPRITAFNDFGERTPSDKPPVKTPGELAIERGEPWPPPEPAKIPEPVGAGYPGAPQVPGQVPNYPPMYPEPGTSGGPTPPVQGNPEPRYPDPGYPDQHHPPQYPNPGYPNPNYPNPGYPNPGNPNPQYPDPGYRDSGSGRTPPEPGGPYGGRTRPDYGAPRDWSAPGWPPESAPRPGRNGEANGWGHRADDDDSRPTS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias641-655Pro residues
Compositional bias668-738Pro residues
Compositional bias794-808Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002907
EMBL· GenBank· DDBJ
AFR50554.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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