J9S1B1 · J9S1B1_9ACTN
- ProteinPhosphomethylpyrimidine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids880 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Catalytic activity
- 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP
Cofactor
Pathway
Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | hydroxymethylpyrimidine kinase activity | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphomethylpyrimidine kinase activity | |
Biological Process | thiamine biosynthetic process | |
Biological Process | thiamine diphosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomethylpyrimidine synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia
Accessions
- Primary accessionJ9S1B1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 25-83 | ThiC-associated | |||
Region | 417-498 | Disordered | |||
Compositional bias | 429-444 | Basic and acidic residues | |||
Region | 514-558 | Disordered | |||
Compositional bias | 533-558 | Basic and acidic residues | |||
Domain | 615-865 | Pyridoxamine kinase/Phosphomethylpyrimidine kinase | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length880
- Mass (Da)95,326
- Last updated2012-11-28 v1
- MD5 ChecksumF24C965A44E7E37C1D800D4A80676385
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 429-444 | Basic and acidic residues | |||
Compositional bias | 533-558 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002907 EMBL· GenBank· DDBJ | AFR47155.1 EMBL· GenBank· DDBJ | Genomic DNA |