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J9S1B1 · J9S1B1_9ACTN

  • Protein
    Phosphomethylpyrimidine synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionhydroxymethylpyrimidine kinase activity
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionphosphomethylpyrimidine kinase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomethylpyrimidine synthase
  • EC number

Gene names

    • ORF names
      KTR9_0489

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KTR9
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    J9S1B1

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain25-83ThiC-associated
Region417-498Disordered
Compositional bias429-444Basic and acidic residues
Region514-558Disordered
Compositional bias533-558Basic and acidic residues
Domain615-865Pyridoxamine kinase/Phosphomethylpyrimidine kinase

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    880
  • Mass (Da)
    95,326
  • Last updated
    2012-11-28 v1
  • MD5 Checksum
    F24C965A44E7E37C1D800D4A80676385
MGTRVSATRTDSAPADSGFLTLGPIEGSTKHYLSVHDLRVPQRRIHLTNGEHLDVYDTSGPYTDRSARIDVEQGLAPTRDSWHRPEPIDGASTQLAWARAGIVTDEMRFIAAREGVDAELVRSEVAIGRAVIPANHRHPESEPMIIGKRFAVKVNANIGNSAVRSSISDEVEKMVWATRWGADTIMDLSTGADIHTTREWIIRNSPVPVGTVPVYQALEKVNGDPASLTWELYRDTVIEQAEQGVDYMTVHAGVLLRHVPLTAERVTGIVSRGGSIMAAWCLAHHRESFLYTHFDELCEIFRRYDITFSLGDGLRPGSIADANDEAQFAELRTLGELTTIAKSHGVQVMIEGPGHVPMHKIAENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAMIAQAGTAMLCYVTPKEHLRPPGPRRRQGRRDHIQDRRALRRPRQGAPAGAGTRRRTQQGALRIPLERPVQPRPRSRHRPRLPRRDTARRAGQDGPLLFHVRPQVLLDADLGGCPRLRRGARSRDHRGHRPHDRGGHGGEVGGVRRGREPRVSTARDRRGRLMGTVNAGRRTVDENRRTVDGNQRTVDEQAFVGLPIGPPGSVPTRVLTIAGSDSGGGAGIQADMRTFALLGVHGCVAVTAVTVQNSLGVTGFEEITPQTVAAQIDSVVGDIGVAAAKTGMLASAPIIEAIVEQCGRSGIGRDSSVPLVVDPVCASMHGNQLLADSALDTLRHNLFPLATVVTPNLDEVRLITGIEVTDAASQRDAARALLDLGPRWALVKGGHLRASDQSPDLLYDGEEFIELSHERIDTPHDHGAGDTLAAAIACALAHGLPVPESVAFAKSWVTRCLAAAYPLGAGHGPVNPLWRLGVRSEDQRPS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias429-444Basic and acidic residues
Compositional bias533-558Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002907
EMBL· GenBank· DDBJ
AFR47155.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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