J9RNE3 · J9RNE3_9ACTN
- ProteinPyruvate dehydrogenase E1 component
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids964 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate + H+ = N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 295 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 325 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 327 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate dehydrogenase E1 component
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia
Accessions
- Primary accessionJ9RNE3
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 28-49 | Polar residues | |||
Region | 28-55 | Disordered | |||
Domain | 197-366 | Transketolase N-terminal | |||
Domain | 551-766 | Pyruvate dehydrogenase E1 component middle | |||
Domain | 782-916 | Transketolase-like C-terminal | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length964
- Mass (Da)106,278
- Last updated2012-11-28 v1
- MD5 ChecksumDAE016EEC216797F0307394238A0BDD1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 28-49 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002907 EMBL· GenBank· DDBJ | AFR49747.1 EMBL· GenBank· DDBJ | Genomic DNA |