J9HGJ1 · LTRIN_AEDAE

Function

function

Inhibits multimerization of host lymphotoxin-beta receptor (LTBR) and downstream NF-kappa-B signaling activation.
(Microbial infection) Attenuates activation of host NF-kappa-B signaling and production of proinflammatory cytokines, such as IL6 and TNF, during Zika virus infection (PubMed:29507355).
Reduces recruitment of host neutrophils and macrophages into the circulating blood and spleen in mice infected with Zika virus (PubMed:29507355).
Up-regulates expression of host AXL during infection with Zika virus and promotes Zika virus replication partially through increased AXL-mediated entry of the virus (PubMed:29507355).

Miscellaneous

Injection of antibodies against the lymphotoxin beta receptor inhibitor one hour before mosquito feeding decreases mosquito-mediated infection with Zika virus in a mouse model.

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Can also bind Zn2+ with low affinity; the presence of Zn2+ causes protein precipitation (PubMed:38248473).
Does not interact with Mg2+ (PubMed:38248473).

Temperature Dependence

Thermostable.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site123Ca2+ 1 (UniProtKB | ChEBI)
Binding site125Ca2+ 1 (UniProtKB | ChEBI)
Binding site127Ca2+ 1 (UniProtKB | ChEBI)
Binding site129Ca2+ 1 (UniProtKB | ChEBI)
Binding site134Ca2+ 1 (UniProtKB | ChEBI)
Binding site180Ca2+ 2 (UniProtKB | ChEBI)
Binding site182Ca2+ 2 (UniProtKB | ChEBI)
Binding site184Ca2+ 2 (UniProtKB | ChEBI)
Binding site186Ca2+ 2 (UniProtKB | ChEBI)
Binding site191Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Biological Processimmune system process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lymphotoxin beta receptor inhibitor
  • Short names
    LTRIN
  • Alternative names
    • EF-hand calcium-binding protein
    • Salivary factor LTRIN

Gene names

    • ORF names
      AaeL_AAEL017253

Organism names

  • Taxonomic identifier
  • Strain
    • Liverpool
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia

Accessions

  • Primary accession
    J9HGJ1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis123Enhances interaction with host LTBR.
Mutagenesis133Does not affect dimerization.
Mutagenesis180Disrupts interaction with host LTBR.

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501430559621-210Lymphotoxin beta receptor inhibitor

Expression

Tissue specificity

Female salivary gland (at protein level).

Induction

Induced in the salivary glands by blood feeding (at protein level) (PubMed:29507355).
Induced in the midgut by blood feeding (PubMed:29507355).

Interaction

Subunit

Homodimer (PubMed:38248473).
Interacts with host LTBR; the interaction reduces dimerization and trimerization of LTBR induced by lymphotoxin (PubMed:29507355, PubMed:38248473).

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region29-80Disordered
Domain110-145EF-hand 1
Domain167-202EF-hand 2

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    210
  • Mass (Da)
    24,343
  • Last updated
    2012-10-31 v1
  • Checksum
    3AC0694863E1F1D5
MKQLALLTLTLLYFAAVALGQRVAPGVNPGHYQQQQQQQPQYQQPQVPVQPQYQQAPVPQQQQQQHQQPPQGHAPHHGQPQQVLNANNIQQEKAHIAEHMDVPIDTSKMSEQELQFHYFKMHDSDNNNKLDGCELIKSLIHWHDEEKHKHAEKNPDEPDKTIYTDEQLENIVDSVMRMMDANGDGYVDYAEYRRSGVEENRRDDYPNGRP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH477824
EMBL· GenBank· DDBJ
EJY57957.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

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