J9HGJ1 · LTRIN_AEDAE
- ProteinLymphotoxin beta receptor inhibitor
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids210 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Inhibits multimerization of host lymphotoxin-beta receptor (LTBR) and downstream NF-kappa-B signaling activation.
(Microbial infection) Attenuates activation of host NF-kappa-B signaling and production of proinflammatory cytokines, such as IL6 and TNF, during Zika virus infection (PubMed:29507355).
Reduces recruitment of host neutrophils and macrophages into the circulating blood and spleen in mice infected with Zika virus (PubMed:29507355).
Up-regulates expression of host AXL during infection with Zika virus and promotes Zika virus replication partially through increased AXL-mediated entry of the virus (PubMed:29507355).
Reduces recruitment of host neutrophils and macrophages into the circulating blood and spleen in mice infected with Zika virus (PubMed:29507355).
Up-regulates expression of host AXL during infection with Zika virus and promotes Zika virus replication partially through increased AXL-mediated entry of the virus (PubMed:29507355).
Miscellaneous
Injection of antibodies against the lymphotoxin beta receptor inhibitor one hour before mosquito feeding decreases mosquito-mediated infection with Zika virus in a mouse model.
Cofactor
Temperature Dependence
Thermostable.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 123 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 127 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 129 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 134 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 180 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 182 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 184 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 186 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 191 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Biological Process | immune system process |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameLymphotoxin beta receptor inhibitor
- Short namesLTRIN
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia
Accessions
- Primary accessionJ9HGJ1
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 123 | Enhances interaction with host LTBR. | ||||
Sequence: D → A | ||||||
Mutagenesis | 133 | Does not affect dimerization. | ||||
Sequence: C → Q | ||||||
Mutagenesis | 180 | Disrupts interaction with host LTBR. | ||||
Sequence: D → A |
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MKQLALLTLTLLYFAAVALG | ||||||
Chain | PRO_5014305596 | 21-210 | Lymphotoxin beta receptor inhibitor | |||
Sequence: QRVAPGVNPGHYQQQQQQQPQYQQPQVPVQPQYQQAPVPQQQQQQHQQPPQGHAPHHGQPQQVLNANNIQQEKAHIAEHMDVPIDTSKMSEQELQFHYFKMHDSDNNNKLDGCELIKSLIHWHDEEKHKHAEKNPDEPDKTIYTDEQLENIVDSVMRMMDANGDGYVDYAEYRRSGVEENRRDDYPNGRP |
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 29-80 | Disordered | ||||
Sequence: PGHYQQQQQQQPQYQQPQVPVQPQYQQAPVPQQQQQQHQQPPQGHAPHHGQP | ||||||
Domain | 110-145 | EF-hand 1 | ||||
Sequence: SEQELQFHYFKMHDSDNNNKLDGCELIKSLIHWHDE | ||||||
Domain | 167-202 | EF-hand 2 | ||||
Sequence: QLENIVDSVMRMMDANGDGYVDYAEYRRSGVEENRR |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length210
- Mass (Da)24,343
- Last updated2012-10-31 v1
- Checksum3AC0694863E1F1D5
Keywords
- Technical term