J9F199 · J9F199_WUCBA
- Proteindihydrofolate reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids172 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 19 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 24 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 56 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 57 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 58 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 78 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 79 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 80 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 117 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 118 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | dihydrofolate reductase activity | |
Molecular Function | NADP binding | |
Biological Process | dihydrofolate metabolic process | |
Biological Process | folic acid metabolic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedihydrofolate reductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Wuchereria
Accessions
- Primary accessionJ9F199
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)19,681
- Last updated2012-10-31 v1
- Checksum0EE8574C54DEC948
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ADBV01000160 EMBL· GenBank· DDBJ | EJW88273.1 EMBL· GenBank· DDBJ | Genomic DNA |