J8PY91 · J8PY91_SACAR

Function

function

Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

1833100200300400500600700800
TypeIDPosition(s)Description
Binding site204-212ATP (UniProtKB | ChEBI)
Binding site227ATP (UniProtKB | ChEBI)
Active site319Proton acceptor

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA replication origin binding
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Biological Processdeoxyribonucleoside triphosphate biosynthetic process
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair
Biological ProcessDNA replication initiation
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase RAD53
  • EC number

Gene names

    • ORF names
      SU7_3519

Organism names

Accessions

  • Primary accession
    J8PY91

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain66-116FHA
Domain198-466Protein kinase
Region517-545Disordered
Domain613-676FHA
Region749-784Disordered
Region806-833Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    833
  • Mass (Da)
    93,774
  • Last updated
    2012-10-31 v1
  • Checksum
    DD62474F6B6BD071
MENITQPTQQSTQATQRFLIEKFSQEQIGENIVCRVICTTGQIPIRDLSADISQILKEKRSIKKVWTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLNDISTNGTWLNGQKVEKNNNQLLSQGDEITVGVGVESDILSLVIFINDKFRQSLEQNKADWIRSNIKNTSKIASPGLTSSTASAVMAHKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLDHPRIVRLKGFYEDSDSYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAVKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDSSVSPEEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNDRLTAAKALDHPWIKMNPFGSQSFGDFSQISLSQSLSQQKILENMDDAQYEFVKAQRRLQLEQQQIVQEQDREQEQDQEQDQEDRDGKIQEFKIPAHPPIRYTQPKSIETDCREQKIMHSNNTTNTKSAKKKGNGRFLTLQPLPDSIIQESLEIQQGVNPFFIGRSEDCNCKIEDNRLSRVHCFIFKKRHAVGKSMYESPAQGLDDIWYCHTGTNVSYLNNSRMIQGTKFLLQDGDEIKIIWDKNNNFVIGFKVEINDTTGLFNDGLGILQEQRVIMKQTTDEKDLVKRLSQMMAAQRANQSPVSSLPITTKKSPISVSSNNSNNSVSSNLVETPINANTGNILKRIHSVSLSQSQIDPSKKVKRAKLDQTSKDPENLQFS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ALIE01000193
EMBL· GenBank· DDBJ
EJS41406.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp