J8PY91 · J8PY91_SACAR
- ProteinSerine/threonine-protein kinase RAD53
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids833 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
Catalytic activity
- L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA replication origin binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein serine/threonine/tyrosine kinase activity | |
Molecular Function | protein tyrosine kinase activity | |
Biological Process | deoxyribonucleoside triphosphate biosynthetic process | |
Biological Process | DNA damage checkpoint signaling | |
Biological Process | DNA repair | |
Biological Process | DNA replication initiation | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase RAD53
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionJ8PY91
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 66-116 | FHA | ||||
Sequence: WTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLNDISTNGTWLNGQKV | ||||||
Domain | 198-466 | Protein kinase | ||||
Sequence: SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLDHPRIVRLKGFYEDSDSYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAVKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDSSVSPEEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNDRLTAAKALDHPWI | ||||||
Region | 517-545 | Disordered | ||||
Sequence: QIVQEQDREQEQDQEQDQEDRDGKIQEFK | ||||||
Domain | 613-676 | FHA | ||||
Sequence: FFIGRSEDCNCKIEDNRLSRVHCFIFKKRHAVGKSMYESPAQGLDDIWYCHTGTNVSYLNNSRM | ||||||
Region | 749-784 | Disordered | ||||
Sequence: QRANQSPVSSLPITTKKSPISVSSNNSNNSVSSNLV | ||||||
Region | 806-833 | Disordered | ||||
Sequence: QSQIDPSKKVKRAKLDQTSKDPENLQFS |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length833
- Mass (Da)93,774
- Last updated2012-10-31 v1
- ChecksumDD62474F6B6BD071
Keywords
- Technical term