J8LHF5 · J8LHF5_SACAR
- ProteinFatty acid synthase subunit alpha
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1889 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- a (3R)-hydroxyacyl-[ACP] + NADP+ = a 3-oxoacyl-[ACP] + NADPH + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1307 | For beta-ketoacyl synthase activity | ||||
Sequence: C | ||||||
Binding site | 1774 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1774-1776 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: DVE | ||||||
Binding site | 1775 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 1776 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1800 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 1810 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1819-1835 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: EAVFKSLGVKSLGGGAA | ||||||
Binding site | 1843-1846 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: RVNK | ||||||
Binding site | 1873-1875 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: ISH | ||||||
Binding site | 1874 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1875 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | fatty acid synthase complex | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | fatty acid synthase activity | |
Molecular Function | fatty-acyl-CoA synthase activity | |
Molecular Function | holo-[acyl-carrier-protein] synthase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | long-chain fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid synthase subunit alpha
- EC number
Including 2 domains:
- Recommended name3-oxoacyl-[acyl-carrier-protein] reductase
- EC number
- Recommended name3-oxoacyl-[acyl-carrier-protein] synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionJ8LHF5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 183 | O-(pantetheine 4'-phosphoryl)serine | ||||
Sequence: S |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 148-223 | Carrier | ||||
Sequence: VKASLLLHVLVSHKLKKPLDSIPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETPLEELAEVFQDTFSGA | ||||||
Domain | 1125-1659 | Ketosynthase family 3 (KS3) | ||||
Sequence: QEVIVEEDLEPFEASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLKGATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVDPITLFVLVSVVEAFISSGITDPYEMYKYVHVSEVGNCSGSGMGGVSALRGMFKDRYKDQPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGACATSVESVDIGVETILSGKAKICIVGGYDDFQEEGSYEFGNMKATSDTFEEFEHGRTPAEMSRPATTTRNGFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNIKYRKRQLITREGQIKDWVENELEALKLEAEEIPAEDQNEFLLERTREIHSEAEMQLRSAQQQWGNDFYKRDPRIAPLRGALATYGLTIDDLGVASFHGTSTKANDKNESATINEMMKHLGRSEGNPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRNADNIDKLLEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAVVVH |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,889
- Mass (Da)207,152
- Last updated2012-10-31 v1
- ChecksumD5FEBA8DBF0F1E4E
Keywords
- Technical term