J7R958 · J7R958_ECOLX
- ProteinBifunctional protein HldE
- GenehldE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids477 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
Catalytic activity
- D-glycero-beta-D-manno-heptose 1-phosphate + ATP + H+ = ADP-D-glycero-beta-D-manno-heptose + diphosphate
Pathway
Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 195-198 | ATP (UniProtKB | ChEBI) | |||
Active site | 264 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | heptose 7-phosphate kinase activity | |
Molecular Function | heptose-1-phosphate adenylyltransferase activity | |
Molecular Function | phosphotransferase activity, alcohol group as acceptor | |
Biological Process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process | |
Biological Process | lipopolysaccharide core region biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein HldE
Including 2 domains:
- Recommended nameD-beta-D-heptose 7-phosphate kinase
- EC number
- Alternative names
- Recommended nameD-beta-D-heptose 1-phosphate adenylyltransferase
- EC number
- Alternative names
Gene names
Encoded on
- Plasmid unnamed7
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionJ7R958
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 179 | N6-acetyllysine | |||
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-318 | Ribokinase | |||
Domain | 13-305 | Carbohydrate kinase PfkB | |||
Domain | 344-469 | Cytidyltransferase-like | |||
Region | 344-477 | Cytidylyltransferase | |||
Sequence similarities
In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length477
- Mass (Da)51,051
- Last updated2012-10-31 v1
- MD5 Checksum8C74D913E2FC37C6A6D92D97771B0E31
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP024092 EMBL· GenBank· DDBJ | ATP24947.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024978 EMBL· GenBank· DDBJ | ATZ33411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024141 EMBL· GenBank· DDBJ | AUJ99610.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP031546 EMBL· GenBank· DDBJ | AXO08959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAUZHL010000003 EMBL· GenBank· DDBJ | CAK1211734.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASATZ010000021 EMBL· GenBank· DDBJ | EFA4419261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASCBU010000003 EMBL· GenBank· DDBJ | EFA8783279.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASCJS010000003 EMBL· GenBank· DDBJ | EFA9844421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASDBN010000010 EMBL· GenBank· DDBJ | EFB1697326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASDFP010000025 EMBL· GenBank· DDBJ | EFB2193156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFMQ010000005 EMBL· GenBank· DDBJ | EFB3614506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFZR010000014 EMBL· GenBank· DDBJ | EFB4532080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEPP010000035 EMBL· GenBank· DDBJ | EFC2247933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASHPR010000006 EMBL· GenBank· DDBJ | EFC3523905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEBA010000023 EMBL· GenBank· DDBJ | EFC9750360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASKVF010000003 EMBL· GenBank· DDBJ | EFD6883266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASOHJ010000010 EMBL· GenBank· DDBJ | EFE8673497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASRHK010000005 EMBL· GenBank· DDBJ | EFF8952954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASSGK010000002 EMBL· GenBank· DDBJ | EFG2159402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASUOH010000001 EMBL· GenBank· DDBJ | EFH0041398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASURL010000027 EMBL· GenBank· DDBJ | EFH0365738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASVQO010000004 EMBL· GenBank· DDBJ | EFH3672919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWBF010000003 EMBL· GenBank· DDBJ | EFH4959537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWIS010000002 EMBL· GenBank· DDBJ | EFH5891165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWKH010000002 EMBL· GenBank· DDBJ | EFH6093580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWKX010000009 EMBL· GenBank· DDBJ | EFH6165317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWOY010000012 EMBL· GenBank· DDBJ | EFH6648601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASZRA010000014 EMBL· GenBank· DDBJ | EFI6953394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATCLQ010000001 EMBL· GenBank· DDBJ | EFJ6479825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJKW010000015 EMBL· GenBank· DDBJ | EFL9837691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJOC010000004 EMBL· GenBank· DDBJ | EFM0252499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJQG010000008 EMBL· GenBank· DDBJ | EFM0516226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJYL010000001 EMBL· GenBank· DDBJ | EFM1443824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATLXB010000009 EMBL· GenBank· DDBJ | EFM7860157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATLZG010000014 EMBL· GenBank· DDBJ | EFM8154810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVQAW010000026 EMBL· GenBank· DDBJ | EGD0650689.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVTXU010000076 EMBL· GenBank· DDBJ | EGE1989429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000010 EMBL· GenBank· DDBJ | EMM0024784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BFIH01000046 EMBL· GenBank· DDBJ | GCO30166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BFXY01000135 EMBL· GenBank· DDBJ | GDH56601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABALL010000012 EMBL· GenBank· DDBJ | HAH1419034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABCJL010000007 EMBL· GenBank· DDBJ | HAH7769889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABERK010000009 EMBL· GenBank· DDBJ | HAI5331994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKZ010000003 EMBL· GenBank· DDBJ | HAJ5149333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKQ010000003 EMBL· GenBank· DDBJ | HAJ5803581.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000005 EMBL· GenBank· DDBJ | HAJ5957812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADPIR010000009 EMBL· GenBank· DDBJ | HAZ7491453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADRWU010000001 EMBL· GenBank· DDBJ | HBA4245178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000005 EMBL· GenBank· DDBJ | HBB1572299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LGZN01000012 EMBL· GenBank· DDBJ | KNF71259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LDYI01000154 EMBL· GenBank· DDBJ | KPO05700.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABFNF010000001 EMBL· GenBank· DDBJ | MBA1884815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACGTG010000001 EMBL· GenBank· DDBJ | MBA6238942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABXPW010000003 EMBL· GenBank· DDBJ | MBA7720070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABWMK020000003 EMBL· GenBank· DDBJ | MBB2464981.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZOI010000028 EMBL· GenBank· DDBJ | MBE0977936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAETYU010000001 EMBL· GenBank· DDBJ | MBL6201804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACCJF010000016 EMBL· GenBank· DDBJ | MBZ4694499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOVKC010000002 EMBL· GenBank· DDBJ | MCV5620744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JANWOR010000667 EMBL· GenBank· DDBJ | MDA4180531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUKXU010000001 EMBL· GenBank· DDBJ | MDO2572788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JANFIP010000005 EMBL· GenBank· DDBJ | MDS0704759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWIHY010000047 EMBL· GenBank· DDBJ | MDV1989593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RNLZ01000042 EMBL· GenBank· DDBJ | MGE15695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ROAL01000025 EMBL· GenBank· DDBJ | MIB62970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RTJF01000008 EMBL· GenBank· DDBJ | MJL93047.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000006 EMBL· GenBank· DDBJ | MQK23376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SQQU01000005 EMBL· GenBank· DDBJ | MQS29498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WKUE01000033 EMBL· GenBank· DDBJ | MSI70784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WOET01000013 EMBL· GenBank· DDBJ | MUM74013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXM01000031 EMBL· GenBank· DDBJ | MWF50920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTML01000023 EMBL· GenBank· DDBJ | MWK97453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTMQ01000002 EMBL· GenBank· DDBJ | MWL03528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTMY01000023 EMBL· GenBank· DDBJ | MWL44852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTOM01000021 EMBL· GenBank· DDBJ | MWN87024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTQQ01000036 EMBL· GenBank· DDBJ | MWR87678.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRX01000069 EMBL· GenBank· DDBJ | MWU33560.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WXKQ01000006 EMBL· GenBank· DDBJ | NAG19501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000043 EMBL· GenBank· DDBJ | NEM87778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYP010000004 EMBL· GenBank· DDBJ | NEN69450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPU010000009 EMBL· GenBank· DDBJ | NYP85243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPJ010000008 EMBL· GenBank· DDBJ | NYQ38743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOHC01000036 EMBL· GenBank· DDBJ | OJN35843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOKI01000002 EMBL· GenBank· DDBJ | OJR56877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPGR01000001 EMBL· GenBank· DDBJ | OKB73734.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MTPS01000100 EMBL· GenBank· DDBJ | ONG35606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPAF01000025 EMBL· GenBank· DDBJ | OOK27198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NHTF01000030 EMBL· GenBank· DDBJ | OWW55448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MRVZ01000050 EMBL· GenBank· DDBJ | PAU22384.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LDXE02000002 EMBL· GenBank· DDBJ | PBN75503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PITP01000022 EMBL· GenBank· DDBJ | PKD87633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PYRA01000006 EMBL· GenBank· DDBJ | PSY94905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QEMT01000006 EMBL· GenBank· DDBJ | PWH63038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QFSS01000040 EMBL· GenBank· DDBJ | PZZ70012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP056794 EMBL· GenBank· DDBJ | QLY95771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057906 EMBL· GenBank· DDBJ | QMO42479.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP055981 EMBL· GenBank· DDBJ | QMS37926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063369 EMBL· GenBank· DDBJ | QOY30758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP065611 EMBL· GenBank· DDBJ | QPR06805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP070393 EMBL· GenBank· DDBJ | QRZ96817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOGZ01000013 EMBL· GenBank· DDBJ | RDA38360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NPIM01000154 EMBL· GenBank· DDBJ | RVE09954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SHGX01000003 EMBL· GenBank· DDBJ | RZW43061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASD01000009 EMBL· GenBank· DDBJ | SPX17550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASG01000009 EMBL· GenBank· DDBJ | SPX29587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCTY01000009 EMBL· GenBank· DDBJ | SQJ57838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCZA01000015 EMBL· GenBank· DDBJ | SQP82426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFYN01000002 EMBL· GenBank· DDBJ | STD42923.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFZA01000001 EMBL· GenBank· DDBJ | STE04669.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFZL01000002 EMBL· GenBank· DDBJ | STE73383.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGAW01000001 EMBL· GenBank· DDBJ | STG50286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGBT01000002 EMBL· GenBank· DDBJ | STH70034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGCD01000002 EMBL· GenBank· DDBJ | STI15743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGCP01000002 EMBL· GenBank· DDBJ | STI88542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGCU01000001 EMBL· GenBank· DDBJ | STJ09309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDD01000002 EMBL· GenBank· DDBJ | STJ53037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGEE01000003 EMBL· GenBank· DDBJ | STK84209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGEB01000001 EMBL· GenBank· DDBJ | STL04598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGET01000004 EMBL· GenBank· DDBJ | STL81609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFE01000002 EMBL· GenBank· DDBJ | STM21925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFO01000006 EMBL· GenBank· DDBJ | STN13069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGGJ01000004 EMBL· GenBank· DDBJ | STN85890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RROO01000188 EMBL· GenBank· DDBJ | TJF55505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RRNI01000002 EMBL· GenBank· DDBJ | TJH25353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QYOH01000002 EMBL· GenBank· DDBJ | TXU37815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHKY01000002 EMBL· GenBank· DDBJ | TZE50889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000001 EMBL· GenBank· DDBJ | VCW52390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWXJ01000001 EMBL· GenBank· DDBJ | VCY85361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP122634 EMBL· GenBank· DDBJ | WHI02637.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP146670 EMBL· GenBank· DDBJ | WWX72188.1 EMBL· GenBank· DDBJ | Genomic DNA |