J7QAV7 · J7QAV7_ECOLX

  • Protein
    Bifunctional aspartokinase/homoserine dehydrogenase
  • Gene
    metL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processmethionine biosynthetic process
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional aspartokinase/homoserine dehydrogenase

Including 2 domains:

  • Recommended name
    Aspartokinase
  • EC number
  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • Name
      metL
    • Synonyms
      metM
    • ORF names
      ACU57_27220
      , BANRA_02611
      , BANRA_05014
      , BG944_004452
      , BGM66_001684
      , BGZ_04848
      , BMT50_08340
      , BRV02_004030
      , BTQ06_03855
      , BvCmsKKP061_03615
      , C1Q91_004300
      , C3F40_15710
      , C6669_07860
      , C9160_25480
      , CCS08_03645
      , CF22_004385
      , CG704_22610
      , CIG67_10295
      , CR538_24475
      , CTR35_003484
      , CV83915_02122
      , CWS33_22745
      , DL968_19350
      , DS732_01285
      , DTL43_12470
      , E4K51_12745
      , E5H86_20215
      , EIZ93_11410
      , EN85_004023
      , EPS97_17535
      , FJQ40_17925
      , FOI11_015940
      , FOI11_07240
      , G3V95_15255
      , G3W53_14625
      , GAI89_23260
      , GAJ12_22900
      , GNW61_09195
      , GNZ05_18465
      , GP711_22925
      , GP944_15425
      , GQE64_17595
      , GQE86_21905
      , GQM21_10985
      , GQN24_21630
      , HEP30_018960
      , HHH44_004249
      , HKA49_004607
      , HMV95_09560
      , HV109_22650
      , HVY77_24600
      , I6H02_15490
      , IH772_17325
      , J0541_002787
      , J5U05_003722
      , JNP96_01050
      , NCTC11181_02015
      , NCTC11341_02716
      , NCTC8179_05156
      , NCTC8333_05617
      , NCTC8500_05383
      , NCTC8985_04098
      , NCTC9073_00920
      , NCTC9117_05963
      , NCTC9706_02052
      , NY836_13310
      , OFN31_21715
      , P6223_001120
      , RZR61_08775
      , SAMEA3752557_02853
      , WR15_02545

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 453
    • 1199
    • 1409
    • 3512
    • 188143
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    J7QAV7
  • Secondary accessions
    • A0A236MYF1
    • A0A2A2XJB9

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-284Aspartate/glutamate/uridylate kinase
Domain465-600Aspartate/homoserine dehydrogenase NAD-binding
Domain608-803Homoserine dehydrogenase catalytic

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    810
  • Mass (Da)
    88,888
  • Last updated
    2012-10-31 v1
  • MD5 Checksum
    AA5259F56846288964836CAD322A85DC
MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINWLKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADSLISAFVSDLERLAALLDSGINDAVYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLLVQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADPRKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIERVLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLLQFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPVEFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFAREQSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPYDDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYNATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLTEPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNEQMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAIQSDINRLAQLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024978
EMBL· GenBank· DDBJ
ATZ32449.1
EMBL· GenBank· DDBJ
Genomic DNA
CP024141
EMBL· GenBank· DDBJ
AUK03300.1
EMBL· GenBank· DDBJ
Genomic DNA
CP026399
EMBL· GenBank· DDBJ
AUY03080.1
EMBL· GenBank· DDBJ
Genomic DNA
CP031134
EMBL· GenBank· DDBJ
AXG16936.1
EMBL· GenBank· DDBJ
Genomic DNA
CP031546
EMBL· GenBank· DDBJ
AXO05107.1
EMBL· GenBank· DDBJ
Genomic DNA
AASCJS010000034
EMBL· GenBank· DDBJ
EFA9847834.1
EMBL· GenBank· DDBJ
Genomic DNA
AASDBN010000039
EMBL· GenBank· DDBJ
EFB1699269.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEPP010000039
EMBL· GenBank· DDBJ
EFC2248090.1
EMBL· GenBank· DDBJ
Genomic DNA
AASHPR010000035
EMBL· GenBank· DDBJ
EFC3526290.1
EMBL· GenBank· DDBJ
Genomic DNA
AASSGK010000034
EMBL· GenBank· DDBJ
EFG2162901.1
EMBL· GenBank· DDBJ
Genomic DNA
AASURL010000020
EMBL· GenBank· DDBJ
EFH0365272.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWKH010000032
EMBL· GenBank· DDBJ
EFH6097525.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWKX010000040
EMBL· GenBank· DDBJ
EFH6167873.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWOY010000017
EMBL· GenBank· DDBJ
EFH6648919.1
EMBL· GenBank· DDBJ
Genomic DNA
AASXRC010000033
EMBL· GenBank· DDBJ
EFI0215199.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJKW010000033
EMBL· GenBank· DDBJ
EFL9838972.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJQG010000032
EMBL· GenBank· DDBJ
EFM0518313.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVTXU010000091
EMBL· GenBank· DDBJ
EGE1989742.1
EMBL· GenBank· DDBJ
Genomic DNA
ABLFQU030000009
EMBL· GenBank· DDBJ
EMM0024602.1
EMBL· GenBank· DDBJ
Genomic DNA
BFXY01000114
EMBL· GenBank· DDBJ
GDH52736.1
EMBL· GenBank· DDBJ
Genomic DNA
DABALL010000035
EMBL· GenBank· DDBJ
HAH1420797.1
EMBL· GenBank· DDBJ
Genomic DNA
DABFUC010000035
EMBL· GenBank· DDBJ
HAI8960343.1
EMBL· GenBank· DDBJ
Genomic DNA
DABHXT010000011
EMBL· GenBank· DDBJ
HAJ5958525.1
EMBL· GenBank· DDBJ
Genomic DNA
DADRWU010000041
EMBL· GenBank· DDBJ
HBA4248522.1
EMBL· GenBank· DDBJ
Genomic DNA
DADUEU010000016
EMBL· GenBank· DDBJ
HBB1573853.1
EMBL· GenBank· DDBJ
Genomic DNA
WSGM01000020
EMBL· GenBank· DDBJ
KAE9728296.1
EMBL· GenBank· DDBJ
Genomic DNA
LGZN01000009
EMBL· GenBank· DDBJ
KNF71804.1
EMBL· GenBank· DDBJ
Genomic DNA
LDYI01000183
EMBL· GenBank· DDBJ
KPO03140.1
EMBL· GenBank· DDBJ
Genomic DNA
JACGTG010000001
EMBL· GenBank· DDBJ
MBA6239811.1
EMBL· GenBank· DDBJ
Genomic DNA
JABWMK020000037
EMBL· GenBank· DDBJ
MBB2468167.1
EMBL· GenBank· DDBJ
Genomic DNA
JACZOI010000048
EMBL· GenBank· DDBJ
MBE0979040.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOVKC010000034
EMBL· GenBank· DDBJ
MCV5624345.1
EMBL· GenBank· DDBJ
Genomic DNA
JANWOR010000358
EMBL· GenBank· DDBJ
MDA4178366.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWIHY010000012
EMBL· GenBank· DDBJ
MDV1987532.1
EMBL· GenBank· DDBJ
Genomic DNA
RYCF01000029
EMBL· GenBank· DDBJ
MQK24916.1
EMBL· GenBank· DDBJ
Genomic DNA
SQQU01000015
EMBL· GenBank· DDBJ
MQS31031.1
EMBL· GenBank· DDBJ
Genomic DNA
WOET01000014
EMBL· GenBank· DDBJ
MUM74133.1
EMBL· GenBank· DDBJ
Genomic DNA
WSXM01000030
EMBL· GenBank· DDBJ
MWF50896.1
EMBL· GenBank· DDBJ
Genomic DNA
WSXK01000084
EMBL· GenBank· DDBJ
MWF97677.1
EMBL· GenBank· DDBJ
Genomic DNA
WTML01000030
EMBL· GenBank· DDBJ
MWK97709.1
EMBL· GenBank· DDBJ
Genomic DNA
WTOM01000032
EMBL· GenBank· DDBJ
MWN87620.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRX01000022
EMBL· GenBank· DDBJ
MWU32147.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYI010000023
EMBL· GenBank· DDBJ
NEM86838.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYP010000017
EMBL· GenBank· DDBJ
NEN71375.1
EMBL· GenBank· DDBJ
Genomic DNA
MPGR01000001
EMBL· GenBank· DDBJ
OKB72771.1
EMBL· GenBank· DDBJ
Genomic DNA
NHTF01000010
EMBL· GenBank· DDBJ
OWW56700.1
EMBL· GenBank· DDBJ
Genomic DNA
NNAF01000077
EMBL· GenBank· DDBJ
OZO76667.1
EMBL· GenBank· DDBJ
Genomic DNA
MRVZ01000008
EMBL· GenBank· DDBJ
PAU26180.1
EMBL· GenBank· DDBJ
Genomic DNA
PITP01000030
EMBL· GenBank· DDBJ
PKD86837.1
EMBL· GenBank· DDBJ
Genomic DNA
CP056794
EMBL· GenBank· DDBJ
QLY99195.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057293
EMBL· GenBank· DDBJ
QMF69790.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063369
EMBL· GenBank· DDBJ
QOY29908.1
EMBL· GenBank· DDBJ
Genomic DNA
CP065611
EMBL· GenBank· DDBJ
QPR03110.1
EMBL· GenBank· DDBJ
Genomic DNA
CP070393
EMBL· GenBank· DDBJ
QRZ97706.1
EMBL· GenBank· DDBJ
Genomic DNA
QOGZ01000012
EMBL· GenBank· DDBJ
RDA38551.1
EMBL· GenBank· DDBJ
Genomic DNA
NPIM01000121
EMBL· GenBank· DDBJ
RVE13737.1
EMBL· GenBank· DDBJ
Genomic DNA
SCIU01000039
EMBL· GenBank· DDBJ
RXB26819.1
EMBL· GenBank· DDBJ
Genomic DNA
UASD01000005
EMBL· GenBank· DDBJ
SPX09649.1
EMBL· GenBank· DDBJ
Genomic DNA
UCZA01000016
EMBL· GenBank· DDBJ
SQP82594.1
EMBL· GenBank· DDBJ
Genomic DNA
UFYN01000002
EMBL· GenBank· DDBJ
STD40175.1
EMBL· GenBank· DDBJ
Genomic DNA
UGBT01000002
EMBL· GenBank· DDBJ
STH71117.1
EMBL· GenBank· DDBJ
Genomic DNA
UGCO01000001
EMBL· GenBank· DDBJ
STI78745.1
EMBL· GenBank· DDBJ
Genomic DNA
UGDC01000003
EMBL· GenBank· DDBJ
STJ83304.1
EMBL· GenBank· DDBJ
Genomic DNA
UGEB01000001
EMBL· GenBank· DDBJ
STK98233.1
EMBL· GenBank· DDBJ
Genomic DNA
UGFE01000002
EMBL· GenBank· DDBJ
STM26527.1
EMBL· GenBank· DDBJ
Genomic DNA
UGFG01000001
EMBL· GenBank· DDBJ
STM41476.1
EMBL· GenBank· DDBJ
Genomic DNA
UGGJ01000004
EMBL· GenBank· DDBJ
STN84999.1
EMBL· GenBank· DDBJ
Genomic DNA
RRNI01000058
EMBL· GenBank· DDBJ
TJH15668.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVU01000001
EMBL· GenBank· DDBJ
VCW54312.1
EMBL· GenBank· DDBJ
Genomic DNA
UWXJ01000001
EMBL· GenBank· DDBJ
VCY86287.1
EMBL· GenBank· DDBJ
Genomic DNA
CABWJN010000005
EMBL· GenBank· DDBJ
VWN18765.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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