J7QAV7 · J7QAV7_ECOLX
- ProteinBifunctional aspartokinase/homoserine dehydrogenase
- GenemetL
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids810 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Catalytic activity
- L-aspartate + ATP = 4-phospho-L-aspartate + ADPThis reaction proceeds in the forward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | methionine biosynthetic process | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional aspartokinase/homoserine dehydrogenase
Including 2 domains:
- Recommended nameAspartokinase
- EC number
- Recommended nameHomoserine dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionJ7QAV7
- Secondary accessions
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 12-284 | Aspartate/glutamate/uridylate kinase | |||
Domain | 465-600 | Aspartate/homoserine dehydrogenase NAD-binding | |||
Domain | 608-803 | Homoserine dehydrogenase catalytic | |||
Sequence similarities
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length810
- Mass (Da)88,888
- Last updated2012-10-31 v1
- MD5 ChecksumAA5259F56846288964836CAD322A85DC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP024978 EMBL· GenBank· DDBJ | ATZ32449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024141 EMBL· GenBank· DDBJ | AUK03300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP026399 EMBL· GenBank· DDBJ | AUY03080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP031134 EMBL· GenBank· DDBJ | AXG16936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP031546 EMBL· GenBank· DDBJ | AXO05107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASCJS010000034 EMBL· GenBank· DDBJ | EFA9847834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASDBN010000039 EMBL· GenBank· DDBJ | EFB1699269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEPP010000039 EMBL· GenBank· DDBJ | EFC2248090.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASHPR010000035 EMBL· GenBank· DDBJ | EFC3526290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASSGK010000034 EMBL· GenBank· DDBJ | EFG2162901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASURL010000020 EMBL· GenBank· DDBJ | EFH0365272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWKH010000032 EMBL· GenBank· DDBJ | EFH6097525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWKX010000040 EMBL· GenBank· DDBJ | EFH6167873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWOY010000017 EMBL· GenBank· DDBJ | EFH6648919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASXRC010000033 EMBL· GenBank· DDBJ | EFI0215199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJKW010000033 EMBL· GenBank· DDBJ | EFL9838972.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJQG010000032 EMBL· GenBank· DDBJ | EFM0518313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVTXU010000091 EMBL· GenBank· DDBJ | EGE1989742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000009 EMBL· GenBank· DDBJ | EMM0024602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BFXY01000114 EMBL· GenBank· DDBJ | GDH52736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABALL010000035 EMBL· GenBank· DDBJ | HAH1420797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABFUC010000035 EMBL· GenBank· DDBJ | HAI8960343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000011 EMBL· GenBank· DDBJ | HAJ5958525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADRWU010000041 EMBL· GenBank· DDBJ | HBA4248522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000016 EMBL· GenBank· DDBJ | HBB1573853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSGM01000020 EMBL· GenBank· DDBJ | KAE9728296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LGZN01000009 EMBL· GenBank· DDBJ | KNF71804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LDYI01000183 EMBL· GenBank· DDBJ | KPO03140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACGTG010000001 EMBL· GenBank· DDBJ | MBA6239811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABWMK020000037 EMBL· GenBank· DDBJ | MBB2468167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZOI010000048 EMBL· GenBank· DDBJ | MBE0979040.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOVKC010000034 EMBL· GenBank· DDBJ | MCV5624345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JANWOR010000358 EMBL· GenBank· DDBJ | MDA4178366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWIHY010000012 EMBL· GenBank· DDBJ | MDV1987532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000029 EMBL· GenBank· DDBJ | MQK24916.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SQQU01000015 EMBL· GenBank· DDBJ | MQS31031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WOET01000014 EMBL· GenBank· DDBJ | MUM74133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXM01000030 EMBL· GenBank· DDBJ | MWF50896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXK01000084 EMBL· GenBank· DDBJ | MWF97677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTML01000030 EMBL· GenBank· DDBJ | MWK97709.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTOM01000032 EMBL· GenBank· DDBJ | MWN87620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRX01000022 EMBL· GenBank· DDBJ | MWU32147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000023 EMBL· GenBank· DDBJ | NEM86838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYP010000017 EMBL· GenBank· DDBJ | NEN71375.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPGR01000001 EMBL· GenBank· DDBJ | OKB72771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NHTF01000010 EMBL· GenBank· DDBJ | OWW56700.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NNAF01000077 EMBL· GenBank· DDBJ | OZO76667.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MRVZ01000008 EMBL· GenBank· DDBJ | PAU26180.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PITP01000030 EMBL· GenBank· DDBJ | PKD86837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP056794 EMBL· GenBank· DDBJ | QLY99195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057293 EMBL· GenBank· DDBJ | QMF69790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063369 EMBL· GenBank· DDBJ | QOY29908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP065611 EMBL· GenBank· DDBJ | QPR03110.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP070393 EMBL· GenBank· DDBJ | QRZ97706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOGZ01000012 EMBL· GenBank· DDBJ | RDA38551.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NPIM01000121 EMBL· GenBank· DDBJ | RVE13737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SCIU01000039 EMBL· GenBank· DDBJ | RXB26819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASD01000005 EMBL· GenBank· DDBJ | SPX09649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UCZA01000016 EMBL· GenBank· DDBJ | SQP82594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFYN01000002 EMBL· GenBank· DDBJ | STD40175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGBT01000002 EMBL· GenBank· DDBJ | STH71117.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGCO01000001 EMBL· GenBank· DDBJ | STI78745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDC01000003 EMBL· GenBank· DDBJ | STJ83304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGEB01000001 EMBL· GenBank· DDBJ | STK98233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFE01000002 EMBL· GenBank· DDBJ | STM26527.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFG01000001 EMBL· GenBank· DDBJ | STM41476.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGGJ01000004 EMBL· GenBank· DDBJ | STN84999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RRNI01000058 EMBL· GenBank· DDBJ | TJH15668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000001 EMBL· GenBank· DDBJ | VCW54312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWXJ01000001 EMBL· GenBank· DDBJ | VCY86287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABWJN010000005 EMBL· GenBank· DDBJ | VWN18765.1 EMBL· GenBank· DDBJ | Genomic DNA |