J6EQW5 · J6EQW5_TRIAS

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site7phosphate (UniProtKB | ChEBI)
Binding site32-33phosphate (UniProtKB | ChEBI)
Binding site65-66phosphate (UniProtKB | ChEBI)
Site151Important for substrate specificity
Binding site169substrate
Binding site170phosphate (UniProtKB | ChEBI)
Binding site193-195substrate
Site206Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      ; MTAPase
      )

Gene names

    • ORF names
      A1Q1_06553

Organism names

Accessions

  • Primary accession
    J6EQW5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-228Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    30,023
  • Last updated
    2012-10-31 v1
  • Checksum
    D6EAE5E33810C5AE
MCVEVETPWGKPSSPITISSLPDGSQVAFISRHGAAHTITPSEVPARANIAALKHLGVRAVVAFSAVGSLREEIAPGHFVIPDQIIDRTKGIRPDTYFRGEGLVVHSMFGEPFSRQLNRFIAPKVKEILDKEGVSVHTDKTVVCMEGPAFSTRAESLMYRQWGGDIINMSVIPEAKLARECELDYALICTATDYDAWRTDAEPVTVEEVVKTLHTNAGNSRAVAAGILEDVCKHVAAGELTEIKGSMQFACVTRKDVQPKAAREKLSFILPYFSD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ALBS01000336
EMBL· GenBank· DDBJ
EJT45082.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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