J6EPR0 · J6EPR0_TRIAS

Function

function

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site104substrate
Binding site122Zn2+ (UniProtKB | ChEBI)
Binding site124Zn2+ (UniProtKB | ChEBI)
Active site177Proton donor/acceptor
Binding site233Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmethylthioribulose 1-phosphate dehydratase activity
Molecular Functionzinc ion binding
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylthioribulose-1-phosphate dehydratase
  • EC number
  • Short names
    MTRu-1-P dehydratase

Gene names

    • Name
      MDE1
    • ORF names
      A1Q1_04973

Organism names

Accessions

  • Primary accession
    J6EPR0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-260Class II aldolase/adducin N-terminal

Sequence similarities

Belongs to the aldolase class II family. MtnB subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    30,087
  • Last updated
    2012-10-31 v1
  • Checksum
    29A2AA99EAC0363B
MVKIEGYGDITPLSAEAEALVQSQDPEHLCREFYKLGWVTGTGGGISMRKGELVYLAPSGVQKERILPEHMFVLPFAQSAVPKPGSKRDLLRIPSKKGLNESQCTPLFWNAFTMRDAQSCIHTHSQNAGESSFLLTRGTLRPLSEAVGRAVYVANMPVMLTLLLGKDAKSFRISHQEMIKGVRLGGVGKTLAYFNTLEVPIIENTAREEDLTDSMGKAMEEYPDAAAILVRRHGVYVWGPSWESAKTQAECLDYLFEIAVKMLQAGIPLEGDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ALBS01000294
EMBL· GenBank· DDBJ
EJT46424.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help