J6EPR0 · J6EPR0_TRIAS
- ProteinMethylthioribulose-1-phosphate dehydratase
- GeneMDE1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
Catalytic activity
- 5-(methylsulfanyl)ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 104 | substrate | |||
Binding site | 122 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 124 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 177 | Proton donor/acceptor | |||
Binding site | 233 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | methylthioribulose 1-phosphate dehydratase activity | |
Molecular Function | zinc ion binding | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | L-methionine salvage from S-adenosylmethionine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylthioribulose-1-phosphate dehydratase
- EC number
- Short namesMTRu-1-P dehydratase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Trichosporonales > Trichosporonaceae > Trichosporon
Accessions
- Primary accessionJ6EPR0
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,087
- Last updated2012-10-31 v1
- Checksum29A2AA99EAC0363B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ALBS01000294 EMBL· GenBank· DDBJ | EJT46424.1 EMBL· GenBank· DDBJ | Genomic DNA |