J4I919 · J4I919_9APHY
- ProteinPyruvate carboxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1197 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Catalytic activity
- ATP + hydrogencarbonate + pyruvate = ADP + H+ + oxaloacetate + phosphate
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 169 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 253 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 288 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 345 | |||||
Sequence: R | ||||||
Binding site | 591 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 663 | substrate | ||||
Sequence: R | ||||||
Binding site | 765 | Mn2+ (UniProtKB | ChEBI); via carbamate group | ||||
Sequence: K | ||||||
Binding site | 795 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 797 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 930 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | pyruvate carboxylase activity | |
Biological Process | gluconeogenesis | |
Biological Process | pyruvate metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate carboxylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Fibroporiaceae > Fibroporia
Accessions
- Primary accessionJ4I919
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 765 | N6-carboxylysine | ||||
Sequence: K | ||||||
Modified residue | 1166 | N6-biotinyllysine | ||||
Sequence: K |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 47-503 | Biotin carboxylation | ||||
Sequence: PLTKILVANRGEIAIRVFRTSHELAMHTVAIYSFEDRLSAHRQKARTLCSADEAYQVGKGLTPVAAYLAQDDIIRIALEHGVDMIHPGYGFLSENAEFARKVEMAGIAFVGPSPEVIDQLGDKTKARTVALKVGVPVVPGTPGPVDSYVEADSFIKEYGFPVIIKAAMGGGGRGMRVVREQSDFAASFERAVSEAKSAFGDGTVFIERFLERPRHIEVQLLADGEGNTIHLFERDCSVQRRHQKVVEVAPATHLPEEVRQAILADAIKLAKSVGYRNAGTAEFLVDQMGRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLPQLGLSQEAITKRGFAIQCRVTTEDAATGFQPDTGKIEVYRSAGGNGVRLDASSGFAGAQITPHYDSLLVKVSVSGTTYEVARRKMLRALVEFRIRGVKTNIPFLFRLLTHDFIDDTPELFKLVQSQNR | ||||||
Domain | 173-370 | ATP-grasp | ||||
Sequence: RTVALKVGVPVVPGTPGPVDSYVEADSFIKEYGFPVIIKAAMGGGGRGMRVVREQSDFAASFERAVSEAKSAFGDGTVFIERFLERPRHIEVQLLADGEGNTIHLFERDCSVQRRHQKVVEVAPATHLPEEVRQAILADAIKLAKSVGYRNAGTAEFLVDQMGRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAA | ||||||
Domain | 582-856 | Pyruvate carboxyltransferase | ||||
Sequence: VLIMDTTWRDAHQSLLATRLRTIDIANIAKETSYALSNAFSLECWGGATFDVAMRFLYEDPWERLRALRKLVPNIPLQALVRGANGVGYTSYPDNAIYDFSKKAVENGLDIFRVFDSLNYIENVSGTLLKLGIDAAKKAGGVVEAAVCYSGDVANPKLTKYTLQYYLDFVDQLVAEGIHILSIKDMAGLLKPEAAKILIGAIREKYPDLPIHVHSHDTAGISTASMLAAAAAGADVIDVAIDSMSGLTSQPPMGAICSALEQTGMGTGIRYADIQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,197
- Mass (Da)130,523
- Last updated2012-10-31 v1
- Checksum95B833E06FCE40A2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE796980 EMBL· GenBank· DDBJ | CCM00391.1 EMBL· GenBank· DDBJ | Genomic DNA |