J4GGP4 · J4GGP4_9APHY
- ProteinPhosphatidylethanolamine N-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids996 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H+ + S-adenosyl-L-homocysteine
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylethanolamine N-methyltransferase
- EC number
- Short namesPE methyltransferase ; PEAMT ; PEMT
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Fibroporiaceae > Fibroporia
Accessions
- Primary accessionJ4GGP4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 72-89 | Helical | ||||
Sequence: LLNLGLLGLQLVLFAVLP | ||||||
Transmembrane | 95-117 | Helical | ||||
Sequence: VFFLVYFAFWRAAYDLGLGWVLT | ||||||
Transmembrane | 180-200 | Helical | ||||
Sequence: IILLNDFLAYCMFAFTCFRVP | ||||||
Transmembrane | 206-225 | Helical | ||||
Sequence: AVHVMRWIGGIALIAFNLWV | ||||||
Transmembrane | 276-301 | Helical | ||||
Sequence: LIIGSYFVLFVSLAAHAAQFGFLVFF | ||||||
Transmembrane | 465-487 | Helical | ||||
Sequence: LVLHFVHALAWCLFHSFGLGFVL | ||||||
Transmembrane | 619-639 | Helical | ||||
Sequence: AAFFGLALISGSKLVFTLAVV |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MATAEPQSSVRQRRRNSAEV | ||||||
Compositional bias | 328-363 | Polar residues | ||||
Sequence: GRLGKTSSSHTRESSESSVFSSDLNTPSATEGESAT | ||||||
Region | 328-406 | Disordered | ||||
Sequence: GRLGKTSSSHTRESSESSVFSSDLNTPSATEGESATETDEVLTETETETEFVHARQNRNKRRSTSSFGSNSTISDGTYR | ||||||
Compositional bias | 388-406 | Polar residues | ||||
Sequence: RRSTSSFGSNSTISDGTYR | ||||||
Region | 924-945 | Disordered | ||||
Sequence: CKNGQTESDDERDEASGRNPDD | ||||||
Compositional bias | 928-945 | Basic and acidic residues | ||||
Sequence: QTESDDERDEASGRNPDD |
Sequence similarities
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length996
- Mass (Da)113,753
- Last updated2012-10-31 v1
- ChecksumD4798ADDDCF1B1CA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 328-363 | Polar residues | ||||
Sequence: GRLGKTSSSHTRESSESSVFSSDLNTPSATEGESAT | ||||||
Compositional bias | 388-406 | Polar residues | ||||
Sequence: RRSTSSFGSNSTISDGTYR | ||||||
Compositional bias | 928-945 | Basic and acidic residues | ||||
Sequence: QTESDDERDEASGRNPDD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE797213 EMBL· GenBank· DDBJ | CCM05928.1 EMBL· GenBank· DDBJ | Genomic DNA |